Non-Hodgkin Lymphoma - MD Anderson Cancer Center

Lymphomas that do not start in white blood cells are called non-Hodgkin lymphoma. Lymphoma is a general term for cancers that develop in the lymphatic system ( ... 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GMEFellowships Learnaboutourgraduatemedicaleducationresidencyandfellowshipopportunities. Top Non-HodgkinLymphoma We'rehereforyou. Callusat 1-877-632-6789 1-877-632-6789 or requestanappointmentonline. Let'sgetstarted. Requestanappointmentonline. Call Requestappointment MyChart Diagnosis&Treatment CancerTypes Non-HodgkinLymphoma JumpTo: Back Non-HodgkinLymphoma Non-HodgkinLymphomaSymptoms Non-HodgkinLymphomaDiagnosis Non-HodgkinLymphomaTreatment Getdetailsaboutourclinicaltrialsthatarecurrentlyenrollingpatients. ViewClinicalTrials Lymphomaisageneraltermforcancersthatdevelopinthelymphatic system(thetissuesandorgansthatproduce,storeandcarrywhiteblood cells).Lymphomasthatdonotstartinwhitebloodcellsarecalled non-Hodgkinlymphoma. Lymphomaisageneraltermforcancersthatdevelopinthelymphatic system(thetissuesandorgansthatproduce,storeandcarrywhiteblood cells).Lymphomasthatdonotstartinwhitebloodcellsarecalled non-Hodgkinlymphoma. Theymaystartinthebonemarrow,spleen,thymusorlymphnodesandspreadtootherpartsofthebody. Non-Hodgkinlymphomaistheseventhmostcommoncancerinmenandwomeninthenation.AccordingtotheNationalCancerInstitute,morethan77,000newcasesofnon-HodgkinlymphomaarediagnosedeachyearintheUnitedStates. Withearlydiagnosisandadvancedtreatmentmethods,non-Hodgkinlymphomahasahighsurvivalrate.Ifthecancerisconfinedtoasingleregion,ithasaboutan83%survivalrate.Eventhemostadvancedstageofnon-Hodgkinlymphomahasasurvivalrategreaterthan60%. Whatarethepartsofthelymphaticsystem? Thelymphaticsystemcarriesdisease-fightingwhitebloodcellsthroughoutthebody.Itincludes: Lymph:Fluidthatcarrieslymphocytes,atypeofwhitebloodcell,throughthebodyinanetworkoflymphvessels,whichareliketinyveins.Lymphhelpsfightagainstinfectionandcancer. Lymphnodes:Tiny,bean-shapedmassesintheunderarm,pelvis,neck,abdomenandgroin.Theyfilterlymphandstorewhitebloodcellstohelpthebodyfightdisease. Spleen:Anorganontheleftsideoftheabdomenthatmakeslymphocytes,storesbloodcellsandgetsridofoldbloodcells. Thymus:Locatedinthechest,thistinyorganstoreslymphocytes. Tonsils:Thesearenodesinbackofthroatthatproducelymphocytes. Bonemarrow:Thisismaterialinbonesthatproducesbloodcells. Non-HodgkinLymphomaTypes B-celllymphoma B-celllymphomaisthemostcommontypeofnon-Hodgkinlymphomaandmakesup85%of Non-Hodgkinlymphomacases.LearnaboutthetypesofB-celllymphoma. T-celllymphoma T-celllymphomasarerare,comprisinglessthan15%ofnon-Hodgkinlymphomas. PrecursorT-lymphoblasticlymphoma/leukemia Thisextremelyraretypeoflymphomacaneitherbeconsideredaformofacutelymphoblasticleukemia(ALL)orlymphoma,dependingontheamountofbonemarrowinvolvement.Thisdiseasetendstostartbehindthebreastbone,infrontoftheheart.Itcangrowintoalargetumorinthechestthatcancausedifficultybreathing.Itistypicallytreatedwithchemotherapy. PeripheralT-celllymphomas ThelymphomasinthisgroupareallrareandarederivedfrommatureT-cells. CutaneousT-celllymphomas  Thesearelymphomasoftheskin,andtopicaltherapymaybeusedasaninitialtreatment.Theremaybesimultaneousorprogressiveinvolvementofbloodorlymphnodes.ThisdiseaseistreatedintheCutaenousT-cellLymphomaClinic. AdultT-cellleukemia/lymphoma  ThislymphomaisdirectlyrelatedtoinfectionwithHTLV-1virusandismostlylimitedtocountrieswherethatvirusismorecommon,suchastheCaribbean,JapanandpartsofAfrica.It’srareintheU.S. AngioimmunoblasticT-celllymphoma  ThistypeofT-celllymphomamakesuproughly4%ofalllymphomas.Itinvolvesthelymphnodesandliverorspleen.Itcancausefever,skinrashes,weightlossandinfection.Itprogressesquicklyandoftenrecurs. Extranodalnaturalkiller/T-celllymphoma  Thisdiseaseisusuallyfoundinthenoseandupperthroat,butcanattacktheskinandotherorgans.It’smoreheavilyconcentratedinSouthAmericaandpartsofAsia. Enteropathy-associatedintestinalT-celllymphoma(EATL)  Thisisatypeoflymphomafoundintheliningofthedigestivetractandcancauseabdominalpain,nauseaandvomiting.Itcanoccurinthecolon,butismorecommoninthesmallintestine.Twosubtypesexist: Type1EATL–Thissubtypecanoccurinpeoplewithceliacdisease–anauto-immunediseasethatcausesglutenconsumptiontopromptthebody’simmunesystemtoattacktheintestinallining.It’smorecommoninpeoplewithadult-onsetceliacdisease. TypeIIEATL–Thistypeislesscommon,withnolinktoceliacdisease. Anaplasticlargecelllymphoma(ALCL)  Thisisafast-growingT-celllymphoma.Itoccursmoreofteninyoungpeoplethanadultsandaccountsforabout2%oflymphomas.Itiscategorizedbysubtype. PrimarycutaneousALCL–Thissubtypeonlyaffectsskin. SystemicALCL–Thiscanaffecttheskin,aswellasotherorgans.ItisfurthercategorizedbasedonwhetherthereisachangeintheALKgene.ALK-positivetrendsyoungerandcarriesamorefavorableprognosisthanALK-negative. Implant-associatedALCL –Thisisararelymphomathatdevelopsinthebreastsofpeoplewhohavehadimplants.Smooth,asopposedtotextured,implantsurfacescarryareducedrisk.Learnmoreaboutimplant-associatedALCL.  PeripheralT-celllymphomas,nototherwisespecified  Thisisacatch-alltermforT-celllymphomasthatdon’tfitintotheothercategories.Theselymphomascaninvolvethedigestivetract,spleen,liver,skinandbonemarrow,butofteninvolvelymphnodes.Theyaremorelikelytobefoundinpatientsintheir60s.Theyaregenerallywidespread,fast-growingandovertimebecomedifficulttotreatevenafterinitiallyrespondingwelltotreatment. MDAndersonis#1inCancerCare Findoutwhatmakesusdifferent Thelymphaticsystem(clicktoenlarge). Non-Hodgkinlymphomaisclassifiedalsobyhowquicklyitspreads. Low-gradenon-Hodgkinlymphomaincludes: Marginalzonelymphoma Mucosa-associatedlymphoidtissue(MALT)lymphoma Follicularlymphoma Mantlecelllymphoma Intermediategradenon-Hodgkinlymphomaincludes: Diffuselargecelllymphoma Primarymediastinallargecelllymphoma Anaplasticlargecelllymphoma High-gradenon-Hodgkinlymphomaincludes: Burkitt’slymphoma Lymphoblasticlymphoma Relapsednon-Hodgkinlymphoma isdiseasethatcomesbackafteryouhavebeensuccessfullytreatedforNon-Hodgkinlymphoma. Refractorynon-Hodgkinlymphoma isneworrelapseddiseasethatdoesnotrespondtotreatment. Non-HodgkinLymphomaRiskFactors Anythingthatincreasesyourchanceofgettingnon-Hodgkinlymphomaisariskfactor.Althoughscientistsdon’tknowyetwhatcausesnon-Hodgkinlymphoma,somefactorsseemtomakeyoumorelikelytodevelopnon-Hodgkinlymphoma.Theseinclude: Gender:Non-Hodgkinlymphomaisslightlymorecommoninmen Race:Non-HodgkinlymphomaisslightlymorecommoninCaucasians Livinginafarmingcommunity.Somestudiessuggestthatcertainherbicidesandpesticidesmayplayapartinlymphoma,butthishasnotbeenproven Bacteriaorviruses,includinghumanimmunodeficiencyvirus(HIV),Epstein-Barrvirus(EBV),humanT-lymphotropicvirus(HTLV)andthebacteriumHelicobacterpylori Hereditarycancersyndromes Noteveryonewithriskfactorsgetsnon-Hodgkinlymphoma.However,ifyouhaveriskfactors,youshoulddiscussthemwithyourdoctor. Learnmoreaboutnon-Hodgkinlymphoma: Non-Hodgkinlymphomasymptoms Non-Hodgkinlymphomadiagnosis Non-Hodgkinlymphomatreatment Inrarecases,non-Hodgkinlymphomacanbepasseddownfromonegenerationtothenext.Geneticcounselingmayberightforyou.Visitour genetictestingpage tolearnmore. WhychooseMDAndersonfornon-Hodgkinlymphomatreatment? AtMDAnderson'sLymphomaandMyelomaCenter,ourgoalistotreatnon-Hodgkinlymphomawithmethodsthatarestrongonthedisease,butasgentleaspossibleonyourbody. OurLymphomaandMyelomaCenterhandlesmorethan35,000patientvisitseachyear,placingMDAndersonamongthenation’smostactiveandexperiencedprograms.Ourdoctors,nurses,andadvancedpracticeprovidersarefocusedandspecializeonlyinlymphomaormyeloma. Drawinguponawiderangeoftreatmentsforeverystageofdisease,andclinicaltrialsofnovelagents,ourphysiciansdesignatreatmentplanthatisuniquelyyours.We'reconstantlyworkingtobringnewtreatmentstopatients,includingtargetedbiologicalagentsthathelpyourbodyfightthecancer. Throughourwiderangeofover100clinicaltrials,wehaveaccesstomanytreatmentsthatarenotavailableotherplaces.Manyofthesearetreatmentsthatourexpertsdevelopedorled. Formanypatientswithnon-Hodgkinlymphoma,thegoaloftreatmentiscure–tocompletelywipeoutthediseasesothatitnevercomesback.Forotherpatients,themosteffectivecourseistokeepknockingbackthediseaseoveraperiodofmanyyears.Inthesecases,personalizedlong-termcareplansareespeciallyimportant.Inthesesituations,inadditiontothinkingaboutwhattodototreatthecancernow,itisimportanttoalsothinkaboutwhattodonextandwhatotherthingstoconsiderlong-term. Ourmultidisciplinaryapproachbringstogetherteamsofspecializedphysicians,nurses,physicianassistants,dietitians,socialworkersandmanyothers,whoworkcloselytogether–andwithyou–toimproveyourchancesforsuccessfultreatment. GroundbreakingResearch MDAndersonhashelpedadvancethetreatmentofnon-Hodgkinlymphomainmanyareas,includingdevelopmentofnew,leading-edgetreatments.Andwecontinuetoresearchwaystoimproveyourhealthandqualityoflife. AtMDAnderson'sLymphomaandMyelomaCenter,youbenefitfromoneofthemostactiveresearchprogramsintheUnitedStates.Thismeansweareabletoofferawiderangeofclinicaltrials(researchstudies)foreverytypeandstageofnon-Hodgkinlymphoma. Lifeisbeautiful.Iamdrinkingitallinandsavoringeverylittlesip. JenniferPonce Survivor TreatmentatMD Anderson Lymphoma&MyelomaCenter ProtonTherapyCenter StemCellTransplantation&CellularTherapyCenter MDAndersonLymphomaandMyelomaCenter FeaturedArticles Newmomfacesthreecancerdiagnoses CutaneousTcelllymphoma:Whenarashisactuallycancer 7questionsaboutfollicularlymphoma,answered Non-Hodgkinlymphomasurvivor:WhyItraveledmorethan7,000milesfromJordanforcancertreatment Radiationtreatmentforbloodcancers StageIVmantlecelllymphomasurvivor:‘Cancerpatientshavehope’ 7questionsaboutdouble-hitlymphoma,answered MantlecelllymphomasurvivorcreatesCOVID-19-killingcomputergame Viewmore Viewless B-CellLymphomaMoonShot MDAnderson’sB-CellLymphomaMoonShot®aimstorapidlyanddramaticallyimprovetreatmentoutcomesforNon-Hodgkinlymphomapatientsthroughpowerfulnewtreatmentapproachesandresearch. LearnmoreabouttheB-CellLymphomaMoonShot ClinicalTrials MDAndersonpatientshaveaccesstoclinicaltrialsoffering promisingnewtreatmentsthatcannotbefoundanywhere else.  ViewClinicalTrials KnowledgeCenter Findthelatestnewsandinformationaboutnon-Hodgkinlymphomain ourKnowledgeCenter,includingblogposts,articles,videos,news releasesandmore. BrowseResources myCancerConnection Talktosomeonewhosharesyourcancerdiagnosisandbematchedwith asurvivor.  LearnMore Prevention&Screening Manycancerscanbepreventedwithlifestylechangesandregular screening.  LearnMore Counseling MDAndersonhaslicensedsocialworkerstohelppatientsandtheir lovedonescopewithcancer. LearnMore Help#EndCancer GiveNow Yourgiftwillhelpmakeatremendousdifference. $100 DonateBlood Ourpatientsdependonbloodandplateletdonations. Learnmore Volunteer Changethelivesofcancerpatientsbygivingyourtimeandtalent.