Punicalagin | 3CLpro Inhibitor - MedChemExpress

Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) ... —MasterofBioactiveMolecules Hello,Signin FindYourLocalDistributor MyAccount Cart(0) EN JP-日本語 EN-English FR-Français DE-Deutsch ES-Español KR-한국어 UnitedStates Canada UnitedKingdom Australia Germany France Japan KoreaSouth Switzerland Algeria Argentina Austria Belgium Brazil Chile Croatia CzechRepublic Denmark Finland HongKong,China Hungary India Iraq Ireland Israel Italy Lebanon Luxembourg Malaysia Mexico Morocco Netherlands NewZealand Norway Pakistan Peru Philippines Poland Portugal Qatar Russia SaudiArabia Serbia Singapore Slovakia Slovenia SouthAfrica Spain Sweden Taiwan,China Thailand Tunisia Turkey Ukraine Macao,China OtherCountries SignalingPathways Home Products ScreeningLibraries RecombinantProteins Kits ContactUs OurService Literature 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BulkandCustomSynthesisService MetabolomicsService ADC-RelatedCustomServices PROTAC-RelatedCustomServices CustomPeptideSynthesis ProteinExpressionService VirtualScreening Cell-basedCompoundScreening IonChannelScreening KinaseScreeningService GPCRBioassayScreeningServices MolarityCalculator DilutionCalculator Events Careers Anti-infection SARS-CoV HBV Punicalagin Punicalagin  Cat.No.:HY-N0063 Purity:99.80% DataSheet SDS HandlingInstructions PunicalaginisapolyphenolingredientisolatedfromPomegranate(PunicagranatumL.)ortheleavesofTerminaliacatappaL..Punicalaginisareversibleandnon-competitive3CLproinhibitorandinhibitsSARS-CoV-2replicationinvitro.Punicalaginisananti-hepatitisBvirus(HBV)agentandhasantioxidant,anti-inflammatory,andanticancereffects.PunicalaginhasthepotentialfortheresearchofCOVID-19. Forresearchuseonly.Wedonotselltopatients. PunicalaginChemicalStructure CASNo.:65995-63-3 Size Price Stock Quantity 5mg USD55 In-stock 0 1 2 3 4 5 6 7 EstimatedTimeofArrival:December31 10mg USD99 In-stock 0 1 2 3 4 5 6 7 EstimatedTimeofArrival:December31 20mg USD165 In-stock 0 1 2 3 4 5 6 7 EstimatedTimeofArrival:December31 50mg   Getquote   100mg   Getquote   or BulkInquiry *PleaseselectQuantitybeforeaddingitems. CustomerReview Basedon3publication(s)inGoogleScholar 3PublicationsCitingUseofMCEPunicalagin •AntioxidRedoxSignal.2021Apr28. •AntivirRes.2021,105075. •JChromatogrA.24December2021,462784. PoweredbyBioz SeemoredetailsonBioz FeaturedRecommendations •RelatedScreeningLibraries: CovalentScreeningLibraryPlus NaturalProductLibraryPlus DrugRepurposingCompoundLibraryPlus ClinicalCompoundLibraryPlus BioactiveCompoundLibraryPlus Anti-InfectionCompoundLibrary NaturalProductLibrary Anti-CancerCompoundLibrary ClinicalCompoundLibrary AntiviralCompoundLibrary DrugRepurposingCompoundLibrary CovalentScreeningLibrary TerpenoidsLibrary PhenolsLibrary Food-SourcedCompoundLibrary Anti-CancerNaturalProductLibrary AntiviralTraditionalChineseMedicineActiveCompoundLibrary Plant-SourcedNaturalProductLibrary HumanMetaboliteLibrary TraditionalChineseMedicineActiveCompoundLibrary BiologicalActivity Purity&Documentation References CustomerReview Description PunicalaginisapolyphenolingredientisolatedfromPomegranate(PunicagranatumL.)ortheleavesofTerminaliacatappaL..Punicalaginisareversibleandnon-competitive3CLproinhibitorandinhibitsSARS-CoV-2replicationinvitro.Punicalaginisananti-hepatitisBvirus(HBV)agentandhasantioxidant,anti-inflammatory,andanticancereffects.PunicalaginhasthepotentialfortheresearchofCOVID-19[1][2][3]. InVitro Punicalagin(100mg/ml)inducesapoptosisinHT-29,HCT116coloncells[1]. PunicalaginslightlyinhibitsthePLproactivitywithanIC50ofover50μM.PunicalagininhibitstheplaqueformationofSARS-CoV-2inadose-dependentmanner,withEC50valuesof7.20μM[4]. Punicalaginbindsatanallostericsiteinthedimerinterface.PunicalagininhibitSARS-CoV-2replicationbyamechanismotherthanpreventingS-mediatedviralentry[4]. MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly. InVivo Punicalagin(10mg/kg)inhibitstheedemarateof58.15%inrats[2]. MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly. ClinicalTrial MolecularWeight 1084.72 Formula C48H28O30 CASNo. 65995-63-3 SMILES O=C1C2=C(C3=C(O)C(O)=C2C4=C(O)C(O)=C(O)C=C4C(OC(C(OC5=O)C(C=O)OC(C6=C(C7=C5C=C(O)C(O)=C7O)C(O)=C(O)C(O)=C6)=O)C8O)=O)C9=C(C(O3)=O)C(C(C(O)=C(O)C(O)=C%10)=C%10C(OC8)=O)=C(O)C(O)=C9O1 StructureClassification Phenols Polyphenols Source Plants Punicaceae PunicagranatumL. Shipping RoomtemperatureincontinentalUS;mayvaryelsewhere. Storage 4°C,protectfromlight *Insolvent:-80°C,6months;-20°C,1month(protectfromlight) Solvent&Solubility InVitro:  DMSO:50mg/mL(46.09mM;Needultrasonic) PreparingStockSolutions Concentration Solvent Mass 1mg 5mg 10mg 1mM 0.9219mL 4.6095mL 9.2190mL 5mM 0.1844mL 0.9219mL 1.8438mL 10mM 0.0922mL 0.4609mL 0.9219mL *Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent. InVivo: 1. Addeachsolventonebyone: 10%DMSO  40%PEG300  5%Tween-80  45%salineSolubility:≥2.17mg/mL(2.00mM);Clearsolution 2. Addeachsolventonebyone: 10%DMSO  90%(20%SBE-β-CDinsaline)Solubility:≥2.17mg/mL(2.00mM);Clearsolution *Alloftheco-solventsareavailablebyMCE. References [1].SeeramNP,etal.In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagicacid anda total pomegranate tannin extract are enhanced in combination with otherpolyphenols asfoundin pomegranate juice.JNutrBiochem. 2005Jun;16(6):360-7. [2].LinCC,etal.Effectsofpunicalaginandpunicalinoncarrageenan-inducedinflammationinrats.AmJChinMed. 1999;27(3-4):371-6. [3].LiuC,etal.Identificationofhydrolyzabletannins(punicalagin, punicalin andgeraniin)asnovelinhibitorsofhepatitisBviruscovalentlyclosedcircularDNA.AntiviralRes. 2016Oct;134:97-107. [4].RuikunDu,etal.DiscoveryofChebulagicAcidandPunicalaginasNovelAllostericInhibitorsofSARS-CoV-23CLpro.AntivirRes.2021,105075. Purity:99.90% SelectBatch: HY-N0063-122845 HY-N0063-123980 HY-N0063-61504 HY-N0063-104409 HY-N0063-123472 HY-N0063-83857 DataSheet(283KB) SDS(393KB) COA(263KB) HNMR(388KB) LCMS(96KB) HandlingInstructions(2659KB) [1].SeeramNP,etal.In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagicacid anda total pomegranate tannin extract are enhanced in combination with otherpolyphenols asfoundin pomegranate juice.JNutrBiochem. 2005Jun;16(6):360-7. [2].LinCC,etal.Effectsofpunicalaginandpunicalinoncarrageenan-inducedinflammationinrats.AmJChinMed. 1999;27(3-4):371-6. [3].LiuC,etal.Identificationofhydrolyzabletannins(punicalagin, punicalin andgeraniin)asnovelinhibitorsofhepatitisBviruscovalentlyclosedcircularDNA.AntiviralRes. 2016Oct;134:97-107. [4].RuikunDu,etal.DiscoveryofChebulagicAcidandPunicalaginasNovelAllostericInhibitorsofSARS-CoV-23CLpro.AntivirRes.2021,105075. Rating LotNumber* SubmitanImage Nofilechosen (Maximumsizeis:1024Kb) PubMedID Ifyouhavepublishedthiswork,pleaseenterthePubMedID. ShowMyName Yournamewillappearonthesite. Email Remarks MolarityCalculator DilutionCalculator Themolaritycalculatorequation Mass(g)=Concentration(mol/L)×Volume(L)×MolecularWeight(g/mol) Mass   Concentration   Volume   MolecularWeight* kg g mg μg ng pg = M mM μM nM pM × L mL μL × Thedilutioncalculatorequation Concentration(start)×Volume(start)=Concentration(final)×Volume(final) Thisequationiscommonlyabbreviatedas:C1V1=C2V2 Concentration(start) × Volume(start) = Concentration(final) × Volume(final) M mM μM nM pM × L mL μL = M mM μM nM pM × L mL μL C1   V1   C2   V2 Keywords: Punicalagin65995-63-3SARS-CoVHBVSARScoronavirusHepatitisBvirusAntioxidantpolyphenolingredientPomegranateantioxidantanti-inflammatoryanticancerInhibitorinhibitorinhibit YourRecentlyViewedProducts: InquiryOnline Yourinformationissafewithus.*RequiredFields. ProductName   Salutation Dr. Prof. Mr. Ms. Mrs. Miss. 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