C. elegans core Taiwan (CECF)

CECF - To share C. elegans resources and to promote C. elegans research in Taiwan. c.eleganscorefacilitytaiwan   ASERVICEFROMNTU,NTHUandNCKU          welcome goalsandmissions overviewofservices announcements E-learning database(login) contactus            sssearchthissite:   C.eleganspublicationsfromTAIWAN     WelcometotheCECFTaiwan ThenematodewormCaenorhabditiseleganshasbecomeanimportanttoolinthescientificworldresultinginover23,000publicationsuntilnow.Fullysequencedgenome,3-daylifecycleandaconsiderablehighamountofprotein-codinggenes(21,000)withhighhomologytohumansmakingitanattractivemodelorganism. OurgoalistoincreasescientificawarenessaboutthisimportantmodelorganismandourmissionistoassistcreatingupnewC.eleganslabsinTaiwanandtooffernon-profitservicesforexistingworm-labs. Usingwormasaresearchtoolishighlybeneficialbasedonitslowcostanditseasinesstobeadaptedafterseveraltrainingcourses.WewishtosupportinvestigatorsduringtheirtransitionfromsinglecellresearchtoC.elegansbasedmodelorganismresearchprovidingmethodicallyassistance,sharingmutantstrainsandplasmids,trainingstudentsandofferinglecturesaboutC.elegansbasedresearch. OurmissionistoprovideknowledgetohelpresearcherstodesignandconductexperimentswithoutC.elegansexperience.Weassistindevelopingexperimentstotestvarioushypothesisinthenematodethathavebeenotherwiseinvestigatedonlyincellcultureorothermodels.   DownloadalistofallwormPIsinTaiwan!   Selected2016-2018publicationsfromtheTaiwanC.eleganscommunity:     Dr.OliverWagner CilialengthandintraflagellartransportregulationbykinasesPKG-1andGCK-2inC.eleganssensoryneurons.MolCellBiol.2018Jan29.doi:10.1128/MCB.00612-17.[Epubaheadofprint]. CoverMCBvol.38,no.7(2018) Dr.OliverWagner UptakeofTiO2NanoparticlesintoC.elegansNeuronsNegativelyAffectsAxonalGrowthandWormLocomotionBehavior.ACSApplMaterInterfaces.2018Feb21.doi:10.1021/acsami.7b18818.[Epubaheadofprint] Dr.JohnWang Non-MendelianassortmentofhomologousautosomesofdifferentsizesinmalesistheancestralstateintheCaenorhabditislineage.SciRep.2017Oct9;7(1):12819. Dr.Han-ShengChuang Analyzingthelocomotorygaitprintof Caenorhabditiselegansonthebasisofempiricalmodedecomposition.PLoSOne.2017Jul24;12(7):e0181469. Dr.Chung-MinLiao Toxicity-basedtoxicokinetic/toxicodynamicassessmentofbioaccumulationandnanotoxicityofzerovalentironnanoparticlesinCaenorhabditis elegans.IntJNanomedicine2017Jun26;12:4607-4621. Dr.Ben-YangLiao RecruitmentofhistonemodificationstoassistmRNAdosagemaintenanceafterdegenerationofcytosineDNAmethylationduringanimalevolution.GenomeRes.2017Sep;27(9):1513-1524. Dr.DanielTsun-YeeChiu/Dr.Sze-chengJohnLo Impairedembryonic development inglucose-6-phosphatedehydrogenase-deficientCaenorhabditis elegans duetoabnormalredoxhomeostasisinducedactivationofcalcium-independentphospholipaseandalterationofglycerophospholipidmetabolism.CellDeathDis.2017Jan12;8(1):e2545. Dr.Chun-LiangPan AWnt-planarpolaritypathwayinstructsneuritebranchingbyrestrictingF-actinassemblythroughendosomalsignaling.PLoSGenet.2017Apr6;13(4):e1006720. Dr.Ben-YangLiao modPhEA:modelorganismPhenotypeEnrichmentAnalysisofeukaryoticgenesets.Bioinformatics.2017Nov1;33(21):3505-3507. Dr.VivianHsiu-ChuanLiao N-γ-(L-Glutamyl)-L-selenomethionineenhancesstressresistanceandamelioratesagingindicatorsviatheselenoproteinTRXR-1inCaenorhabditiselegans.MolNutrFoodRes.2017Aug;61(8). Dr.Yen-PingHsueh   Nematophagousfungus Arthrobotrysoligospora mimicsolfactorycuesofsexandfoodtolureitsnematodeprey.Elife.2017Jan18;6. Dr.VivianHsiu-ChuanLiao ChronicZnO-NPsexposureatenvironmentallyrelevantconcentrationsresultsinmetabolicandlocomotivetoxicitiesinCaenorhabditiselegans.EnvironPollut.2017Jan;220(PtB):1456-1464. Dr.Chang-ShiChen ADiseaseModelofMuscleNecrosisCausedbyAeromonasdhakensisInfectioninCaenorhabditiselegans.FrontMicrobiol.2017Jan4;7:2058. Dr.Chang-ShiChen HLH-30/TFEB-mediatedautophagyfunctionsinacell-autonomousmannerforepitheliumintrinsiccellulardefenseagainstbacterialpore-formingtoxininC.elegans.Autophagy.2017Feb;13(2):371-385. Dr.Sze-chengJohnLo ExpressionofhepatitisBvirussurfaceantigensinducesdefectivegonadphenotypesinCaenorhabditis elegans.WorldJVirol.2017Feb12;6(1):17-25. Dr.Yi-ChunWu/Dr.Hung-Yuan(Pater)Chi Functionalcharacterizationofthemeiosis-specificDNAdouble-strandbreakinducingfactorSPO-11from C.elegans.SciRep.2017May24;7(1):2370. Dr.DanielTsun-YeeChiu Whathaspassedisprolog:newcellularandphysiologicalrolesofG6PD.FreeRadicRes.2016Oct19:1-18. Dr.Chun-LiangPan AC. elegansThermosensoryCircuitRegulatesLongevitythroughcrh-1/CREB-Dependentflp-6NeuropeptideSignaling.DevCell.2016Oct24;39(2):209-223. Dr.VivianHsiu-ChuanLiao TransgenerationalReproductiveEffectsofArseniteAreAssociatedwithH3K4DimethylationandSPR-5DownregulationinCaenorhabditiselegans.EnvironSciTechnol.2016Oct4;50(19):10673-10681. Dr.Chang-ShiChen MutationoftheEnterohemorrhagicEscherichiacoliCoreLPSBiosynthesisEnzymeRfaDConfersHypersusceptibilitytoHostIntestinalInnateImmunityInvivo.FrontCellInfectMicrobiol.2016Aug12;6:82. Dr.VivianHsiu-ChuanLiao MonascinfromMonascus-FermentedProductsReducesOxidativeStressandAmyloid-βToxicityviaDAF-16/FOXOinCaenorhabditiselegans.JAgricFoodChem.2016Sep28;64(38):7114-20. Dr.Ta-ChauChang/Dr.Sze-chengJohnLo SpecificpolyunsaturatedfattyacidsmodulatelipiddeliveryandoocytedevelopmentinC.elegansrevealedbymolecular-selectivelabel-freeimaging.SciRep.2016Aug18;6:32021. Dr.Yi-ChunWu ProgrammedCellDeathDuringCaenorhabditiselegansDevelopment.Genetics.2016Aug;203(4):1533-62. Dr.Yuan,Hanna OxidativeStressImpairsCellDeathbyRepressingtheNucleaseActivityofMitochondrialEndonucleaseG.CellRep.2016Jul12;16(2):279-87 Dr.Yuan,Hanna MitochondrialendonucleaseGmediatesbreakdownofpaternalmitochondriauponfertilization.Science.2016Jul22;353(6297):394-9. Dr.Chang-ShiChen Exerciseinanelectrotacticflowchamberamelioratesage-relateddegenerationinCaenorhabditiselegans.SciRep.2016Jun16;6:28064 Dr.Chein-ChiaWang AWHEPDomainRegulatestheDynamicStructureandActivityofCaenorhabditiselegans Glycyl-tRNASynthetase.JBiolChem.2016Aug5;291(32):16567-75. Dr.Chung-MinLiao Insituremediation-releasedzero-valentironnanoparticlesimpairsoilecosystemshealth:AC.elegansbiomarker-basedriskassessment.JHazardMater.2016Nov5;317:210-20. Dr.VivianHsiu-ChuanLiao AntioxidativeActivitiesofBothOleicAcidand Camelliatenuifolia SeedOilAreRegulatedbytheTranscriptionFactorDAF-16/FOXOin Caenorhabditiselegans.PLoSOne.2016Jun8;11(6):e0157195. Dr.OliverWagner IdentificationandCharacterizationofLIN-2(CASK)asaRegulatorofKinesin-3UNC-104(KIF1A)MotilityandClusteringinNeurons.Traffic.2016Aug;17(8):891-907. Dr.Sze-chengJohnLo Geneticcontrolofnucleolarsize:Anevolutionaryperspective.Nucleus.2016Apr25;7(2):112-20. Dr.VivianHsiu-ChuanLiao Nanoscalezerovalentiron(nZVI)atenvironmentallyrelevantconcentrationsinducedmultigenerationalreproductivetoxicityinCaenorhabditiselegans.Chemosphere.2016May;150:615-23 Dr.VivianHsiu-ChuanLiao ArseniteexposureacceleratesagingprocessregulatedbythetranscriptionfactorDAF-16/FOXOinCaenorhabditis elegans.Chemosphere.2016May;150:632-8 Dr.Shih-PengChan AnovelfunctionfortheDEAD-boxRNAhelicaseDDX-23inprimarymicroRNAprocessinginCaenorhabditis elegans.DevBiol.2016Jan15;409(2):459-72. Dr.Hao-ChiehChiu InvitroandinvivoactivityofanovelsorafenibderivativeSC5005againstMRSA.JAntimicrobChemother.2016Feb;71(2):449-59. Dr.Yi-ChunWu/Dr.Chao-PingHsu Noisepropagationwithinterlinkedfeed-forwardpathways.SciRep.2016Mar31;6:23607. Dr.Chang-ShiChen HLH-30/TFEB-mediatedautophagyfunctionsinacell-autonomousmannerforepitheliumintrinsiccellulardefenseagainstbacterialpore-formingtoxininC.elegans.Autophagy.2016Nov22:0.[Epubaheadofprint] TheCECFconsistsofthreecores,thenorthcoreatNTU,thecentercoreatNTHUandthesouthcoreatNCKU: Thanksforvisitingusandwehopeservingyousoon!   OURSERVICES MicroinjectionFacilityatNTHU. Readmore> GeneGun(BiolisticParticleDeliverySystem)atNCKU. Readmore> CenterforStrainandVectorCollectionatNTU. Readmore> RNAilibraryscreeningandMicroplateReaderatNCKU. Readmore> SupportforExperimentalDesign. Readmore>