Turmeric - Uses, Side Effects, and More - WebMD

Overview; Uses; Side Effects; Precautions; Interactions; Dosing; Reviews (373) ... Because curcumin and other chemicals in turmeric might decrease swelling, ... MENUVITAMINS&SUPPLEMENTSCENTERFindaVitaminorSupplementFindaVitaminbyConditionAssessYourVitaminNeedsDRUGSANDMEDICATIONSCENTERFindaDrugMyMedicinePillIdentifierInteractionCheckerLatestDrugNewsFindaVitaminFindaPharmacyFIRSTAIDRESOURCESFirstAidA-ZFirstAidKit&WoundCareFirstAidMobileRELATEDTOVITAMINS&SUPPLEMENTSDrugs&MedicationsPillIdentifierMyMedicineInteractionCheckerDiet&WeightManagementFood&RecipesVitamins&SupplementsturmericTURMERIC-Uses,SideEffects,andMoreOTHERNAME(S):Curcuma,Curcumaaromatica,Curcumadomestica,Cur...ShowMoreOTHERNAME(S):Curcuma,Curcumaaromatica,Curcumadomestica,Cur...ShowMoreOverviewUsesSideEffectsPrecautionsInteractionsDosingReviews(373)OverviewTurmericisacommonspicethatcomesfromtherootofCurcumalonga.Itcontainsachemicalcalledcurcumin,whichmightreduceswelling.Turmerichasawarm,bittertasteandisfrequentlyusedtoflavororcolorcurrypowders,mustards,butters,andcheeses.Becausecurcuminandotherchemicalsinturmericmightdecreaseswelling,itisoftenusedtotreatconditionsthatinvolvepainandinflammation.Peoplecommonlyuseturmericforosteoarthritis.Itisalsousedforhayfever,depression,highcholesterol,atypeofliverdisease,anditching,butthereisnogoodscientificevidencetosupportmostoftheseuses.ThereisalsonogoodevidencetosupportusingturmericforCOVID-19.Don'tconfuseturmericwithJavaneseturmericrootortreeturmeric.Also,don'tconfuseitwithzedoaryorgoldenseal,whichareunrelatedplantsthataresometimescalledturmeric.Uses&Effectiveness?PossiblyEffectiveforHayfever.Takingturmericbymouthseemstoreducehayfeversymptomssuchassneezing,itching,runnynose,andcongestion.Depression.Mostresearchshowsthattakingcurcumin,achemicalfoundinturmeric,bymouthreducesdepressionsymptomsinpeoplealreadyusinganantidepressant.Highlevelsofcholesterolorotherfats(lipids)intheblood(hyperlipidemia).Takingturmericbymouthseemstolowerlevelsofbloodfatscalledtriglycerides.Buttheeffectsofturmericoncholesterollevelsareconflicting.Also,therearemanydifferentturmericproductsavailable.Itisnotknownwhichonesworkbest.Buildupoffatintheliverinpeoplewhodrinklittleornoalcohol(nonalcoholicfattyliverdiseaseorNAFLD).Takingturmericextractbymouthreducesmarkersofliverinjuryinpeoplewhohavethiscondition.Italsoseemstohelppreventthebuild-upofmorefatintheliver.Swelling(inflammation)andsoresinsidethemouth(oralmucositis).Takingcurcumin,achemicalfoundinturmeric,bymouth,orasalozengeormouthwash,seemstopreventswellingandsoresinthemouthduringradiationtreatmentforcancer.Osteoarthritis.Takingturmericextracts,aloneortogetherwithotherherbalingredients,canreducepainandimprovefunctioninpeoplewithkneeosteoarthritis.Turmericmightworkaboutaswellasibuprofenforreducingpain.Butitdoesn'tseemtoworkaswellasanotherdrug,calleddiclofenac.Itching.Takingturmericbymouthmightreduceitchingthatiscausedbyvariousconditions.PossiblyIneffectiveforAlzheimerdisease.Takingturmeric,orachemicalinturmericcalledcurcumin,bymouthdoesnotseemtoimprovesymptomsofAlzheimerdisease.Stomachulcers.Takingturmericbymouthdoesnotseemtoimprovestomachulcers.Thereisinterestinusingturmericforanumberofotherpurposes,butthereisn'tenoughreliableinformationtosaywhetheritmightbehelpful.SideEffectsWhentakenbymouth:Turmericislikelysafewhenusedshort-term.Turmericproductsthatprovideupto8gramsofcurcumindailyseemtobesafewhenusedforupto2months,Also,takingupto3gramsofturmericdailyseemstobesafewhenusedforupto3months.Turmericusuallydoesn'tcauseserioussideeffects.Somepeoplecanexperiencemildsideeffectssuchasstomachupset,nausea,dizziness,ordiarrhea.Thesesideeffectsaremorecommonathigherdoses.Whenappliedtotheskin:Turmericislikelysafe.Itispossiblysafewhenturmericisappliedinsidethemouthasamouthwash.Whenappliedintotherectum:Turmericispossiblysafewhenusedasanenema.SpecialPrecautionsandWarningsWhentakenbymouth:Turmericislikelysafewhenusedshort-term.Turmericproductsthatprovideupto8gramsofcurcumindailyseemtobesafewhenusedforupto2months,Also,takingupto3gramsofturmericdailyseemstobesafewhenusedforupto3months.Turmericusuallydoesn'tcauseserioussideeffects.Somepeoplecanexperiencemildsideeffectssuchasstomachupset,nausea,dizziness,ordiarrhea.Thesesideeffectsaremorecommonathigherdoses.Whenappliedtotheskin:Turmericislikelysafe.Itispossiblysafewhenturmericisappliedinsidethemouthasamouthwash.Whenappliedintotherectum:Turmericispossiblysafewhenusedasanenema.Pregnancy:Turmericiscommonlyusedinsmallamountsasaspiceinfoods.Butit'slikelyunsafetouselargeramountsofturmericasamedicineduringpregnancy.Itmightcauseamenstrualperiodorstimulatetheuterus,puttingthepregnancyatrisk.Donottakemedicinalamountsofturmericifyouarepregnant.Breast-feeding:Turmericiscommonlyusedinsmallamountsasaspiceinfoods.Butthereisn'tenoughreliableinformationtoknowifturmericissafetouseinmedicinalamountsduringbreast-feeding.Stayonthesafesideandavoiduse.Gallbladderproblems:Turmericcanmakegallbladderproblemsworse.Donotuseturmericifyouhavegallstonesorabileductobstruction.Bleedingproblems:Takingturmericmightslowbloodclotting.Thismightincreasetheriskofbruisingandbleedinginpeoplewithbleedingdisorders.Hormone-sensitiveconditionsuchasbreastcancer,uterinecancer,ovariancancer,endometriosis,oruterinefibroids:Turmericcontainsachemicalcalledcurcumin,whichmightactlikethehormoneestrogen.Intheory,thismighthaveeffectsonhormone-sensitiveconditions.Untilmoreisknown,usecautiouslyifyouhaveaconditionthatmightbemadeworsebyexposuretohormones.Infertility:Turmericmightlowertestosteronelevelsanddecreasespermmovement.Thismightreducefertility.Turmericshouldbeusedcautiouslybypeopletryingtohaveababy.Liverdisease:Thereissomeconcernthatturmericcandamagetheliver,especiallyinpeoplewhohaveliverdisease.Don'tuseturmericifyouhaveliverproblems.Surgery:Turmericmightslowbloodclotting.Itmightcauseextrableedingduringandaftersurgery.Stopusingturmericatleast2weeksbeforeascheduledsurgery.Interactions?ModerateInteractionBecautiouswiththiscombinationMedicationsthatslowbloodclotting(Anticoagulant/Antiplateletdrugs)interactswithTURMERICTurmericmightslowbloodclotting.Takingturmericalongwithmedicationsthatalsoslowbloodclottingmightincreasetheriskofbruisingandbleeding.Medicationsfordiabetes(Antidiabetesdrugs)interactswithTURMERICTurmericmightlowerbloodsugarlevels.Takingturmericalongwithdiabetesmedicationsmightcausebloodsugartodroptoolow.Monitoryourbloodsugarclosely.TalinololinteractswithTURMERICTurmericmightdecreasehowmuchtalinololthebodyabsorbs.Takingturmericwhiletakingtalinololmightdecreasetheeffectsoftalinolol.Sulfasalazine(Azulfidine)interactswithTURMERICTurmericmightincreasehowmuchsulfasalazinethebodyabsorbs.Takingturmericwhiletakingsulfasalazinemightincreasetheeffectsandsideeffectsofsulfasalazine.Tacrolimus(Prograf)interactswithTURMERICWarfarin(Coumadin)interactswithTURMERICWarfarinisusedtoslowbloodclotting.Takingturmericwhiletakingwarfarinmightincreasetheeffectsofwarfarinandincreasetheriskofbleedingandbruising.Medicationsforcancer(Alkylatingagents)interactswithTURMERICTurmericisanantioxidant.Thereissomeconcernthatantioxidantsmightdecreasetheeffectsofsomemedicationsusedforcancer.Ifyouaretakingmedicationsforcancer,checkwithyourhealthcareproviderbeforetakingturmeric.Medicationsforcancer(Antitumorantibiotics)interactswithTURMERICTurmericisanantioxidant.Thereissomeconcernthatantioxidantsmightdecreasetheeffectsofmedicationsusedforcancer.Ifyouaretakingmedicationsforcancer,checkwithyourhealthcareproviderbeforetakingturmeric.Medicationsforcancer(TopoisomeraseIinhibitors)interactswithTURMERICTurmericisanantioxidant.Thereissomeconcernthatantioxidantsmightdecreasetheeffectivenessofsomemedicationsusedforcancers.Ifyouaretakingmedicationsforcancer,checkwithyourhealthcareproviderbeforetakingturmeric.Amlodipine(Norvasc)interactswithTURMERICTurmericmightincreasehowmuchamlodipinethebodyabsorbs.Takingturmericwhiletakingamlodipinemightincreasetheeffectsandsideeffectsofamlodipine.Medicationsthatcanharmtheliver(Hepatotoxicdrugs)interactswithTURMERICTurmericmightharmtheliver.Somemedicationscanalsoharmtheliver.Takingturmericalongwithamedicationthatcanharmthelivermightincreasetheriskofliverdamage.Tamoxifen(Soltamox)interactswithTURMERICTurmericmightdecreasehowmuchtamoxifenisinthebody.Takingturmericwithtamoxifenmightdecreasetheeffectsoftamoxifen.MinorInteractionBewatchfulwiththiscombinationMedicationschangedbytheliver(CytochromeP4501A1(CYP1A1)substrates)interactswithTURMERICSomemedicationsarechangedandbrokendownbytheliver.Turmericmightchangehowquicklytheliverbreaksdownthesemedications.Thiscouldchangetheeffectsandsideeffectsofthesemedications.Medicationschangedbytheliver(CytochromeP4501A2(CYP1A2)substrates)interactswithTURMERICSomemedicationsarechangedandbrokendownbytheliver.Turmericmightchangehowquicklytheliverbreaksdownthesemedications.Thiscouldchangetheeffectsandsideeffectsofthesemedications.Medicationschangedbytheliver(CytochromeP4503A4(CYP3A4)substrates)interactswithTURMERICSomemedicationsarechangedandbrokendownbytheliver.Turmericmightchangehowquicklytheliverbreaksdownthesemedications.Thiscouldchangetheeffectsandsideeffectsofthesemedications.EstrogensinteractswithTURMERICLargeamountsofturmericmightinterferewiththeeffectsofestrogen.Takingturmericalongwithestrogenmightdecreasetheeffectsofestrogens. Someestrogenpillsincludeconjugatedequineestrogens(Premarin),ethinylestradiol,estradiol,andothers.Norfloxacin(Noroxin)interactswithTURMERICTurmericmightincreasehowmuchnorfloxacinthebodyabsorbs.Takingturmericwhiletakingnorfloxacinmightincreasetheeffectsandsideeffectsofnorfloxacin.Medicationsmovedbypumpsincells(P-GlycoproteinSubstrates)interactswithTURMERICSomemedicationsaremovedinandoutofcellsbypumps.Turmericmightchangehowthesepumpsworkandchangehowmuchmedicationstaysinthebody.Insomecases,thismightchangetheeffectsandsideeffectsofamedication.Paclitaxel(Abraxane,Onxol)interactswithTURMERICTurmericmightincreasehowmuchpaclitaxelthebodyabsorbs.Takingturmericwhiletakingpaclitaxelmightincreasetheeffectsandsideeffectsofpaclitaxel.However,thereisnotenoughinformationtoknowifthisisabigconcern.Docetaxel(Taxotere)interactswithTURMERICTurmericmightincreasehowmuchdocetaxelthebodyabsorbs.Takingturmericwhiletakingdocetaxelmightincreasetheeffectsandsideeffectsofdocetaxel.Glyburide(Diabeta,others)interactswithTURMERICTurmericcontainscurcumin.Curcuminmightlowerbloodsugar.Glyburideisalsousedtolowerbloodsugar.Takingcurcuminorturmericalongwithglyburidemightcauseyourbloodsugartogotoolow.Monitoryourbloodsugarclosely.Yourdoseofglyburidemightneedtobechanged.DosingTurmerichasmostoftenbeenusedbyadultsindosesofupto1.5gramsdailyforupto9months.Itisalsosometimesusedinmouthwashes,gels,creams,andtonics.Speakwithahealthcareprovidertofindoutwhatdosemightbebestforaspecificcondition.NextViewReferencesREFERENCES:AbdelFattah,E.A.,Hashem,H.E.,Ahmed,F.A.,Ghallab,M.A.,Varga,I.,andPolak,S.Prophylacticroleofcurcuminagainstcyclosporine-inducednephrotoxicity:Histologicalandimmunohistologicalstudy.Gen.PhysiolBiophys.2010;29(1):85-94.Viewabstract.Abraham,S.K.,Sarma,L.,andKesavan,P.C.Protectiveeffectsofchlorogenicacid,curcuminandbeta-caroteneagainstgamma-radiation-inducedinvivochromosomaldamage.Mutat.Res1993;303(3):109-112.Viewabstract.Adhvaryu,M.R.,Reddy,N.,andVakharia,B.C.Preventionofhepatotoxicityduetoantituberculosistreatment:anovelintegrativeapproach.WorldJGastroenterol.8-14-2008;14(30):4753-4762.Viewabstract.Agarwal,K.A.,Tripathi,C.D.,Agarwal,B.B.,andSaluja,S.Efficacyofturmeric(curcumin)inpainandpostoperativefatigueafterlaparoscopiccholecystectomy:adouble-blind,randomizedplacebo-controlledstudy.SurgEndosc.6-14-2011;Viewabstract.Agrawal,D.K.,Saikia,D.,Tiwari,R.,Ojha,S.,Shanker,K.,Kumar,J.K.,Gupta,A.K.,Tandon,S.,Negi,A.S.,andKhanuja,S.P.Demethoxycurcuminanditssemisyntheticanaloguesasantitubercularagents.PlantaMed.2008;74(15):1828-1831.Viewabstract.Ahmed,T.andGilani,A.H.Inhibitoryeffectofcurcuminoidsonacetylcholinesteraseactivityandattenuationofscopolamine-inducedamnesiamayexplainmedicinaluseofturmericinAlzheimer'sdisease.PharmacolBiochem.Behav.2009;91(4):554-559.Viewabstract.Ahmed,T.,Enam,S.A.,andGilani,A.H.Curcuminoidsenhancememoryinanamyloid-infusedratmodelofAlzheimer'sdisease.Neuroscience6-9-2010;Viewabstract.Ahmed,T.,Gilani,A.H.,Hosseinmardi,N.,Semnanian,S.,Enam,S.A.,andFathollahi,Y.Curcuminoidsrescuelong-termpotentiationimpairedbyamyloidpeptideinrathippocampalslices.Synapse2011;65(7):572-582.Viewabstract.AlZanbagi,N.A.andZelai,N.T.TwomethodsforattenuatingToxoplasmagondiitachyzoitesRHstrainbyusingethanolextractofCurcumalonga.JEgyptSoc.Parasitol.2008;38(3):965-976.Viewabstract.Ali,B.H.,AlWabel,N.,Mahmoud,O.,Mousa,H.M.,andHashad,M.Curcuminhasapalliativeactionongentamicin-inducednephrotoxicityinrats.Fundam.ClinPharmacol2005;19(4):473-477.Viewabstract.Allam,G.Immunomodulatoryeffectsofcurcumintreatmentonmurineschistosomiasismansoni.Immunobiology2009;214(8):712-727.Viewabstract.Alves,L.V.,Temporal,R.M.,Cysne-Finkelstein,L.,andLeon,L.L.EfficacyofadiarylheptanoidderivativeagainstLeishmaniaamazonensis.Mem.Inst.OswaldoCruz2003;98(4):553-555.Viewabstract.Arun,N.andNalini,N.Efficacyofturmericonbloodsugarandpolyolpathwayindiabeticalbinorats.PlantFoodsHum.Nutr.2002;57(1):41-52.Viewabstract.Ashok,P.andMeenakshi,B.ContraceptiveeffectofCurcumalonga(L.)inmalealbinorat.AsianJAndrol2004;6(1):71-74.Viewabstract.Azuine,M.A.andBhide,S.V.ChemopreventiveeffectofturmericagainststomachandskintumorsinducedbychemicalcarcinogensinSwissmice.Nutr.Cancer1992;17(1):77-83.Viewabstract.Babu,P.S.andSrinivasan,K.Hypolipidemicactionofcurcumin,theactiveprincipleofturmeric(Curcumalonga)instreptozotocininduceddiabeticrats.Mol.CellBiochem.1997;166(1-2):169-175.Viewabstract.Babu,P.S.andSrinivasan,K.Influenceofdietarycurcuminandcholesterolontheprogressionofexperimentallyinduceddiabetesinalbinorat.Mol.CellBiochem.11-8-1995;152(1):13-21.Viewabstract.Baghdasaryan,A.,Claudel,T.,Kosters,A.,Gumhold,J.,Silbert,D.,Thuringer,A.,Leski,K.,Fickert,P.,Karpen,S.J.,andTrauner,M.CurcuminimprovessclerosingcholangitisinMdr2-/-micebyinhibitionofcholangiocyteinflammatoryresponseandportalmyofibroblastproliferation.Gut2010;59(4):521-530.Viewabstract.Balasubramanian,K.Molecularorbitalbasisforyellowcurryspicecurcumin'spreventionofAlzheimer'sdisease.JAgric.FoodChem.5-17-2006;54(10):3512-3520.Viewabstract.Baliga,M.S.,Jage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