B-cell lymphoma - Wikipedia

The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes. They develop more frequently in older adults ... B-celllymphoma FromWikipedia,thefreeencyclopedia Jumptonavigation Jumptosearch BloodcancerthataffectsB-typewhitebloodcells MedicalconditionB-celllymphomaMicrographshowingalargeBcelllymphoma.Fieldstain.SpecialtyHematology,oncology TheB-celllymphomasaretypesoflymphomaaffectingBcells.Lymphomasare"bloodcancers"inthelymphnodes.Theydevelopmorefrequentlyinolderadultsandinimmunocompromisedindividuals. B-celllymphomasincludebothHodgkin'slymphomasandmostnon-Hodgkinlymphomas.Theyaretypicallydividedintolowandhighgrade,typicallycorrespondingtoindolent(slow-growing)lymphomasandaggressivelymphomas,respectively.Asageneralisation,indolentlymphomasrespondtotreatmentandarekeptundercontrol(inremission)withlong-termsurvivalofmanyyears,butarenotcured.Aggressivelymphomasusuallyrequireintensivetreatments,withsomehavingagoodprospectforapermanentcure.[1] Prognosisandtreatmentdependsonthespecifictypeoflymphomaaswellasthestageandgrade.Treatmentincludesradiationandchemotherapy.Early-stageindolentB-celllymphomascanoftenbetreatedwithradiationalone,withlong-termnon-recurrence.Early-stageaggressivediseaseistreatedwithchemotherapyandoftenradiation,witha70–90%curerate.[1]Late-stageindolentlymphomasaresometimesleftuntreatedandmonitoreduntiltheyprogress.Late-stageaggressivediseaseistreatedwithchemotherapy,withcureratesofover70%.[1] Contents 1Types 1.1Common 1.2Rare 1.3Other 2Diagnosis 3Associatedchromosomaltranslocations 4Seealso 5References 6Externallinks Types[edit] MicrographshowingHodgkin'slymphoma,atypeofBcelllymphomathatisusuallyconsideredseparatefromotherBcelllymphomas.Fieldstain. CTscanofprimaryBcelllymphomaintheleftilium,asdiffusecorticalandtrabecularthickeningofthehemipelvis,mimickingPaget'sdisease.[2] TherearenumerouskindsoflymphomasinvolvingBcells.ThemostcommonlyusedclassificationsystemistheWHOclassification,aconvergenceofmorethanone,olderclassificationsystems.[citationneeded] Common[edit] Fiveaccountfornearlythreeoutoffourpatientswithnon-Hodgkinlymphoma:[3] DiffuselargeB-celllymphoma(DLBCL)[4] Follicularlymphoma MarginalzoneB-celllymphoma(MZL)ormucosa-associatedlymphatictissuelymphoma(MALT) Smalllymphocyticlymphoma(SLL,alsoknownaschroniclymphocyticleukemia,CLL) Mantlecelllymphoma(MCL) Rare[edit] Theremainingformsaremuchlesscommon:[3] DLBCLvariantsorsub-typesof Primarymediastinal(thymic)largeBcelllymphoma Tcell/histiocyte-richlargeB-celllymphoma PrimarycutaneousdiffuselargeB-celllymphoma,legtype(PrimarycutaneousDLBCL,legtype) EBVpositivediffuselargeB-celllymphomaoftheelderly DiffuselargeB-celllymphomaassociatedwithchronicinflammation Fibrin-associateddiffuselargeB-celllymphoma PrimarytesticulardiffuselargeB-celllymphoma Burkitt'slymphoma Lymphoplasmacyticlymphoma,whichmaymanifestasWaldenström'smacroglobulinemia NodalmarginalzoneBcelllymphoma(NMZL) Splenicmarginalzonelymphoma(SMZL) Intravascularlymphomasvariants IntravascularlargeB-celllymphoma IntravascularNK-celllymphoma IntravascularT-celllymphoma Primaryeffusionlymphoma Lymphomatoidgranulomatosis Primarycentralnervoussystemlymphoma ALK+largeB-celllymphoma Plasmablasticlymphoma LargeB-celllymphomaarisinginHHV8-associatedmulticentricCastleman'sdisease B-celllymphoma,unclassifiablewithfeaturesintermediatebetweendiffuselargeB-celllymphomaandBurkittlymphoma B-celllymphoma,unclassifiablewithfeaturesintermediatebetweendiffuselargeB-celllymphomaandclassicalHodgkinlymphoma Other[edit] Additionally,someresearchersseparateoutlymphomasthatappeartoresultfromotherimmunesystemdisorders,suchasAIDS-relatedlymphoma.[citationneeded] ClassicHodgkin'slymphomaandnodularlymphocytepredominantHodgkin'slymphomaarenowconsideredformsofB-celllymphoma.[5] Diagnosis[edit] WhenapersonappearstohaveaB-celllymphoma,themaincomponentsofaworkup(fordeterminingtheappropriatetherapyandtheperson'sprognosis)are:[6] Establishingtheprecisesubtype:Initially,anincisionalorexcisionalbiopsyispreferred.Acoreneedlebiopsyisdiscouragedexceptincasealymphnodeisnoteasilyaccessible.Fine-needleaspirationisonlyacceptableinselectedcircumstances,incombinationwithimmunohistochemistryandflowcytometry. Determiningtheextentofthedisease(localizedoradvanced;nodalorextranodal) Theperson'sgeneralhealthstatus. MainimmunohistochemistrymarkersincommontypesofB-celllymphoma.[7] Follicularlymphoma MarginalzoneB-celllymphoma(MZL)ormucosa-associatedlymphatictissue(MALT)lymphoma Smalllymphocyticlymphoma(SLL)/chroniclymphocyticleukemia(CLL) Mantlecelllymphoma(MCL) CD5 - - + + CD10 + - - - CD23 - - + - CyclinD1 - - - + Associatedchromosomaltranslocations[edit] ChromosomaltranslocationsinvolvingtheimmunoglobulinheavylocusisaclassiccytogeneticabnormalityformanyB-celllymphomas,includingfollicularlymphoma,mantlecelllymphomaandBurkitt'slymphoma.[8]Inthesecases,theimmunoglobulinheavylocusformsafusionproteinwithanotherproteinthathaspro-proliferativeoranti-apoptoticabilities.Theenhancerelementoftheimmunoglobulinheavylocus,whichnormallyfunctionstomakeBcellsproducemassiveproductionofantibodies,nowinducesmassivetranscriptionofthefusionprotein,resultinginexcessivepro-proliferativeoranti-apoptoticeffectsontheBcellscontainingthefusionprotein.[citationneeded] InBurkitt'slymphomaandmantlecelllymphoma,theotherproteininthefusionisc-myc(onchromosome8)andcyclinD1[9](onchromosome11),respectively,whichgivesthefusionproteinpro-proliferativeability.Infollicularlymphoma,thefusedproteinis Bcl-2(onchromosome18),whichgivesthefusionproteinanti-apoptoticabilities.[citationneeded] Seealso[edit] Richter'stransformation T-celllymphoma References[edit] ^abcMerckManualhomeedition,Non-HodgkinLymphomas ^Nguyen,Nghi;Khan,Mujahid;Shah,Muhammad(2017)."PrimaryB-celllymphomaofthepelvicboneinayoungpatient:Imagingfeaturesofararecase".CancerResearchFrontiers.3(1):51–55.doi:10.17980/2017.51.ISSN 2328-5249. ^ab"TheLymphomas"(PDF).TheLeukemia&LymphomaSociety.May2006.p. 12.Archivedfromtheoriginal(PDF)on2008-07-06.Retrieved2008-04-07. ^MazenSanoufa;MohammadSamiWalid;TalatParveen(2010)."B-CellLymphomaoftheThoracicSpinePresentingwithSpinalCordPressureSyndrome".JournalofClinicalMedicineResearch.2(1):53–54.doi:10.4021/jocmr2010.02.258w.PMC 3299178.PMID 22457704. ^"HMDS:Hodgkin'sLymphoma".Archivedfromtheoriginalon4March2009.Retrieved2009-02-01. ^MohammadMuhsinChisti,HareshKumar,SumeetKYadav."B-CellLymphomaWorkup".Medscape.{{citeweb}}:CS1maint:multiplenames:authorslist(link)UpdatedJul27,2020 ^Attanoos,Richard(2018)."LymphoidMalignanciesofthePleuraandPeritoneum".PracticalPathologyofSerousMembranes.pp. 203–208.doi:10.1017/9781316402009.016.ISBN 9781316402009. ^Küppers,R;Dalla-Favera,R(10September2001)."MechanismsofchromosomaltranslocationsinBcelllymphomas"(PDF).Oncogene.20(40):5580–94.doi:10.1038/sj.onc.1204640.PMID 11607811.S2CID 10776403. ^LiJY,GaillardF,MoreauA,et al.(May1999)."Detectionoftranslocationt(11;14)(q13;q32)inmantlecelllymphomabyfluorescenceinsituhybridization".Am.J.Pathol.154(5):1449–52.doi:10.1016/S0002-9440(10)65399-0.PMC 1866594.PMID 10329598. Externallinks[edit] ClassificationDICD-10:C85.1ICD-O:9680/0,9699/3,9699/3MeSH:D016393ExternalresourceseMedicine:med/1358 vteLeukaemias,lymphomasandrelateddiseaseBcell(lymphoma,leukemia)(mostCD19 CD20)Bydevelopment/markerTdT+ ALL(PrecursorBacutelymphoblasticleukemia/lymphoma) CD5+ naiveBcell(CLL/SLL) mantlezone(Mantlecell) CD22+ Prolymphocytic CD11c+(Hairycellleukemia) CD79a+ germinalcenter/follicularBcell(Follicular Burkitt's GCBDLBCL Primarycutaneousfolliclecenterlymphoma) marginalzone/marginalzoneB-cell(Splenicmarginalzone MALT Nodalmarginalzone Primarycutaneousmarginalzonelymphoma) RS(CD15+,CD30+) ClassicHodgkinlymphoma(Nodularsclerosis) CD20+(NodularlymphocytepredominantHodgkinlymphoma) PCDs/PP(CD38+/CD138+) seeimmunoproliferativeimmunoglobulindisorders Byinfection KSHV(Primaryeffusion) EBV Lymphomatoidgranulomatosis Post-transplantlymphoproliferativedisorder ClassicHodgkinlymphoma Burkitt'slymphoma HCV Splenicmarginalzonelymphoma HIV(AIDS-relatedlymphoma) Helicobacterpylori(MALTlymphoma) Cutaneous DiffuselargeB-celllymphoma IntravascularlargeB-celllymphoma Primarycutaneousmarginalzonelymphoma Primarycutaneousimmunocytoma Plasmacytoma Plasmacytosis Primarycutaneousfolliclecenterlymphoma T/NKTcell(lymphoma,leukemia)(mostCD3 CD4 CD8)Bydevelopment/marker TdT+:ALL(PrecursorTacutelymphoblasticleukemia/lymphoma) prolymphocyte(Prolymphocytic) CD30+(Anaplasticlarge-celllymphoma LymphomatoidpapulosistypeA) CutaneousMF+variants indolent:Mycosisfungoides Pagetoidreticulosis Granulomatousslackskin aggressive:Sézarydisease AdultT-cellleukemia/lymphoma Non-MF CD30-:Non-mycosisfungoidesCD30−cutaneouslargeT-celllymphoma PleomorphicT-celllymphoma LymphomatoidpapulosistypeB CD30+:CD30+cutaneousT-celllymphoma SecondarycutaneousCD30+large-celllymphoma LymphomatoidpapulosistypeA Otherperipheral Hepatosplenic Angioimmunoblastic Enteropathy-associatedT-celllymphoma PeripheralT-celllymphomanototherwisespecified(Lennertlymphoma) SubcutaneousT-celllymphoma Byinfection HTLV-1(AdultT-cellleukemia/lymphoma) NKcell/(mostCD56) AggressiveNK-cellleukemia BlasticNKcelllymphoma TorNK EBV(ExtranodalNK-T-celllymphoma/Angiocentriclymphoma) Largegranularlymphocyticleukemia Lymphoid+myeloid Acutebiphenotypicleukaemia Lymphocytosis Lymphoproliferativedisorders(X-linkedlymphoproliferativedisease Autoimmunelymphoproliferativesyndrome) Leukemoidreaction Diffuseinfiltrativelymphocytosissyndrome Cutaneouslymphoidhyperplasia Cutaneouslymphoidhyperplasia withbandlikeandperivascularpatterns withnodularpattern Jessnerlymphocyticinfiltrateoftheskin General Hematologicalmalignancy leukemia Lymphoproliferativedisorders Lymphoidleukemias Retrievedfrom"https://en.wikipedia.org/w/index.php?title=B-cell_lymphoma&oldid=1109598154" Categories:LymphomaHiddencategories:CS1maint:multiplenames:authorslistArticleswithshortdescriptionShortdescriptionisdifferentfromWikidataAllarticleswithunsourcedstatementsArticleswithunsourcedstatementsfromNovember2021ArticleswithunsourcedstatementsfromMarch2021 Navigationmenu Personaltools NotloggedinTalkContributionsCreateaccountLogin Namespaces ArticleTalk English Views ReadEditViewhistory More Search Navigation MainpageContentsCurrenteventsRandomarticleAboutWikipediaContactusDonate Contribute HelpLearntoeditCommunityportalRecentchangesUploadfile Tools WhatlinkshereRelatedchangesUploadfileSpecialpagesPermanentlinkPageinformationCitethispageWikidataitem Print/export DownloadasPDFPrintableversion Languages العربيةEspañol한국어ଓଡ଼ିଆ中文 Editlinks