Curcumin — Health Benefits, Dosage, Side Effects

Curcumin is the primary bioactive substance in turmeric. It has anti-inflammatory properties, and there is decent evidence that it can ... JoinExamine.comforfree × Don'tmissoutonthelatestnutritionandsupplementresearch Enteryouremailandwe'llkeepyouontopofthelatestnutritionresearch,supplementmyths,andmore. I'mreadytolearn Close QuickNavigation Examine.com SupplementsEncyclopedia AntioxidantandAnti-inflammatory Curcumin Curcumin Curcuministheprimarybioactivesubstanceinturmeric.Ithasanti-inflammatoryproperties,andthereisdecentevidencethatitcanalleviatevariousconditions,fromchronicpaintodepression.Curcuminhaspoorbioavailabilityonitsown,andthusitisoftencombinedwithpiperineorwithlipids. Ourevidence-basedanalysisoncurcuminfeatures 341uniquereferencestoscientificpapers. × Thispageisregularlyupdated,toincludethemostrecentlyavailableclinicaltrialevidence. Eachmemberofourresearchteamisrequiredtohavenoconflictsofinterest,includingwithsupplement manufacturers,foodcompanies,andindustryfunders.Theteamincludesnutritionresearchers,registered dietitians,physicians,andpharmacists.Wehaveastricteditorialprocess. Thispagefeatures341references.Allfactualclaimsarefollowedbyspecifically-applicablereferences. Clickheretoseethefullsetofreferences forthispage. Researchanalysisledby AntonisDamianou andreviewedby theExamineteam. LastUpdated:Jun7,2022 SummaryofCurcumin Primaryinformation,healthbenefits,sideeffects,usage,andotherimportantdetails Curcumin—ayellowpigmentfoundprimarilyinturmeric(afloweringplantofthegingerfamilybestknownasaspiceusedincurry)—isapolyphenolwithanti-inflammatorypropertiesandtheabilitytoincreasetheamountofantioxidantsthatthebodyproduces. Curcuminandthecurcuminoidsfoundinturmericcanbeextractedtoproducesupplementsthathaveamuchhigherpotencythanturmeric.However,curcuminisabsorbedpoorlyduringdigestion,soamyriadofdifferentformulationshavebeencreatedtoimproveitsbioavailability. Supplementationwithcurcuminreliablyreducesmarkersofinflammationandincreasesthelevelsofendogenousantioxidantsinthebody.Moreresearchisneededoncurcuminformanyareasofhealth,buttheavailableresearchsupportssmalltomoderateimprovementsinthesymptomsofdepressionandanxietyandinpainandfunctioninosteoarthritis.ReductionsinLDLcholesterol,bloodglucose,andbloodpressurearepossible,buttheresearchontheseoutcomesislimitedandlessconsistent. Oneofcurcumin’sgreatestdrawbacksisthatitispoorlyabsorbedwhenorallyingestedbyitself.Regardingpotentialadverseeffects,dosesofupto8gramsofcurcuminoidshavenotbeenassociatedwithseriousadverseeffectsinhumans.However,long-termstudiesthataremorecomprehensiveintheirassessmentsareneeded.Studiesusinghighdosesofcurcuminhavereportedsomemildadverseeffects,includingnausea,diarrhea,headache,skinrash,andyellowstool.Useofcurcuminwithpiperine(ablackpepperextract)maycauseadversedrugreactionsbecausepiperinegreatlyincreasesintestinalpermeability.Notallformulationsofcurcuminhavebeensafetytestedtothesamedegree. Thepotentialbeneficialeffectsofcurcuminseemtobemainlytheresultofitsanti-inflammatoryandantioxidantproperties.Thesepropertiesaremediatedbycurcumin’sdirectorindirectinteractionwith(andmodulationof)variousmoleculartargets,includingtranscriptionfactors,enzymes,cellcycleproteins,receptors,cellsurfaceadhesionmolecules,growthfactors,andproteinkinases. OurSupplementGuidesgiveyouunbiasedrecommendations—basedonresearch—thatyoucanimmediatelyapplytoimproveyourhealth.YoucanfindcurcumininourJointHealthandMood&DepressionSupplementGuides. History Share Link Follow Printversion Login × Youmustbeloggedbeforeyoucanfollowthispage. Login Register ForgotPassword? Followthispage × YouarenowfollowingCurcumin.Youwillbenotifiedwhenanysignificantupdateismade. Close Unfollowthispage × Doyouwishtounfollowthispage? Unfollow Didyouknowcurcuminhasbeenresearchedinthecontextofmanyconditionsanddiseasestates?Researchsuggestscurcuminimprovesbiomarkersassociatedwithkneeosteoarthritis,ulcerativecolitis,elevatedtriglyceridelevels,type2diabetes,atherosclerosis,andnonalcoholicfattyliverdisease.Nowonderthisgold-coloredcompoundisworthitsweightin…well,gold! Stayuptodateonthisrapidly-evolvingresearchtopicwithanExamineMembership—tryfreefor14days! HowtoTake Recommendeddosage,activeamounts,otherdetails Byitself,curcuminispoorlyabsorbed.Amongthemethodsdevisedtoaddresstheissue,thetwomostcommon(andmostoftentested)aretopaircurcuminwithpiperine(ablackpepperextract)ortocombineitwithlipids(BCM-95®,Meriva®…). Tosupplementcurcuminwithpiperine,take500mgoftheformerwith5-6.7mgofthelatter,thriceaday(i.e.,1,500mgofcurcuminand15-20mgofpiperineperday). TosupplementBCM-95®,apatentedcombinationofcurcuminandessentialoils,take500mgtwiceaday(i.e.,1,000mg/day). TosupplementMeriva®,apatentedcombinationofcurcuminandsoylecithin,take200–500mgtwiceaday(i.e.,400–1,000mg/day). Curcuminisusuallytakentogetherwithfood. Easilystayontopofthelatestnutritionresearch BecomeanExamineMembertogetaccesstothelatestresearch.Get150+studiessummarizedforyouacross25differentcategorieseverymonth. MembersalsohaveaccesstotheExamineStudyDatabaseof400+supplementsandtheireffectson600+healthoutcomes,aswellasin-depthresearchanalyses.Understandthewholebodyofnutritionandsupplementevidenceataglance. Getinstantaccess—startyourfree14-daytrial AlreadyaMember?Clickheretologin. HumanEffectMatrix UnlockedforExamineMembers Easilystayontopofthelatestnutritionresearch BecomeanExamineMembertogetaccesstothelatestresearch.Get150+studiessummarizedforyouacross25differentcategorieseverymonth. MembersalsohaveaccesstotheExamineStudyDatabaseof400+supplementsandtheireffectson600+healthoutcomes,aswellasin-depthresearchanalyses.Understandthewholebodyofnutritionandsupplementevidenceataglance. Getinstantaccess—startyourfree14-daytrial AlreadyaMember?Clickheretologin. TheHumanEffectMatrixsummarizeshumanstudiestotellyouwhateffectsCurcuminhasonyourbody,howmuchevidencethereis,andhowstrongtheseeffectsare. FulldetailsareavailabletoExamineMembers.NotaMember?TryExamineMembershipcompletelyfreefortwoweeks. Grade LevelofEvidence[showlegend] Robustresearchconductedwithrepeateddouble-blindclinicaltrials Multiplestudieswhereatleasttwoaredouble-blindandplacebocontrolled Singledouble-blindstudyormultiplecohortstudies Uncontrolledorobservationalstudiesonly LevelofEvidence ? Theamountofhighqualityevidence.Themore evidence,themorewecantrusttheresults. Outcome Magnitudeofeffect ? Thedirectionandsizeofthesupplement'simpacton eachoutcome.Somesupplementscanhaveanincreasingeffect,othershaveadecreasingeffect,andothershavenoeffect. Consistencyofresearchresults ? Scientificresearchdoesnotalwaysagree.HIGHor VERYHIGHmeansthatmostofthescientificresearchagrees. Notes Triglycerides Minor Moderate Seeall28studies Somereducingeffectshavebeennoted,buttheyseemtobeunreliableandnotoverlypotent Anti-OxidantEnzymeProfile Notable VeryHigh Seeall8studies Althoughtheexactenzymethatincreasesisnotoverlyreliable(SOD,glutathione,andcatalase),allthreeenzymeshaveindividuallybeennotedtobeincreasedandtheytendtodosotoalargedegree. Depression Notable VeryHigh Seeall8studies Curcuminseemstobemoreeffectivethanplaceboinreducingsymptomsofdepression.Itmaytake2-3monthstoseeanyoutcomes.Skepticismiswarrantedthough,asthestudiescomparingcurcumintoplacebowerenotwelldesignedandproducedeffectsizesnottoofarapart,eventhoughthedifferenceswerestatisticallysignificant. Inflammation Notable VeryHigh Seeall6studies Thereappearstobeadecreaseindiseasestatesorconditionscharacterizedbyinflammationassociatedwithcurcuminingestion,doesnotappeartobetoodiscriminatoryinwhichinflammatorystatesitbenefits Pain Notable VeryHigh Seeall15studies Therearedecreasesinpainassociatedwithcurcuminathigherdoseswhichextendtopost-operative,arthritis,andgeneralpainsymptoms.Inparticular,curcuminhasbeenresearchedforosteoarthritisthemost,butmanyofthesestudiesareoflowqualityandfundedbyindustry,socautioniswarranted. SymptomsofOsteoarthritis Notable VeryHigh Seeall13studies Supplementationwithcurcuminresultedinanotable,consistentreductioninosteoarthritissymptomsacrossmanystudies.Oftheosteoarthritissymptoms,itseemstobemosteffectiveforpainandphysicalfunction,whileit'slessclearifitreducesstiffness.Cautionshouldbetakenduetomanyofthestudiesnotbeinghighquality. Anxiety Minor VeryHigh Seeall4studies Issomewhatmoreeffectivethanplaceboinreducingsymptomsofanxiety,specificallystateandtraitanxiety. BloodPressure Minor High Seeall14studies Maydecreasebloodpressure,butmorecontextualevidenceisrequired,suchasenoughstudiestoproperlycompareeffectsinhypertension,type2diabetes,andhealthypeople. Bloodglucose Minor Low Seeall29studies Thereductioninglucoseislikelysmallandinconsistentoverall,andmostlikelytobemeaningfulforpeoplewithtype2diabetics.Itisunlikelythatplainturmerichasnotableeffects,andhighpotencycurcuminoidsaremorelikelytohaveaneffect. C-ReactiveProtein(CRP) Minor High Seeall19studies MaydecreaseC-reactiveproteinifelevated.Studiesaresomewhatinconsistent,butaneffectinthosewhowillbenefitmostislikely. GeneralOxidation Minor VeryHigh Seeall7studies Prooxidativebiomarkersappeartobereducedfollowinglongtermsupplementationofcurcumin High-densitylipoprotein(HDL) Minor Low Seeall27studies PossibleincreasesinHDL-C LipidPeroxidation Minor VeryHigh Seeall7studies Adecreaseinlipidperoxidationresultsfollowingcurcuminingestionchronically LiverEnzymes Minor Moderate Seeall16studies Nosignificantinfluenceonliverenzymesassociatedwithcurcuminsupplementationinmostpeople,however,asmallreductionismorelikelyinpeoplewithelevatedliverenzymes. Low-densitylipoprotein(LDL) Minor Moderate Seeall27studies Asmallreductioninpeoplewithhighcholesterollevelsispossible,butstudiesareinconsistent. GlycemicControl - Moderate Seeall12studies Aneffectispossibleintype2diabeticsbutstudiesarenotgenerallysupportive. HbA1c - VeryHigh Seeall15studies Somestudieshavefoundreductionsbut,evenintype2diabetics,evidenceisinconsistent. Totalcholesterol - VeryHigh Seeall28studies Morerobustevidencesuggestsnosignificantinfluenceofcurcuminontotalcholesterol,althoughtheremaybeapotentialroleinpeoplewithelevatedlipids. Weight - VeryHigh Seeall15studies It'sunclearifthereductionsfoundinsomestudiesaregenuineeffectsorrandomvariance. FunctionalityinElderlyorInjured Notable VeryHigh See2studies Inpersonswithosteoarthritis,theperformanceonatreadmilltestaftereightmonthswassignificantlyincreased(morethantwicethedistancecoveredwithcurcuminrelativetocontrol). NitricOxide Notable - Seestudy 80mgofabioavailabilityenhancedcurcuminsupplementhasbeenreportedtoincreasenitricoxideinserumby40%orso,whichissignificantlylargerthanmanyotherdietarysupplements. Adiponectin Minor VeryHigh Seeall4studies Curcuminhasbeenimplicatedinincreasingadiponectinconcentrations. BloodFlow Minor VeryHigh Seeall5studies Anincreaseinbloodflowhasbeennotedwithcurcuminsupplementation CellAdhesionFactors Minor VeryHigh See2studies Decreasesincelladhesionfactorshavebeennoted,whichmayunderlietherapeuticbenefitstowardsatherosclerosisofcurcuminsupplementation. CognitiveDecline Minor - Seestudy Rateofcognitivedeclinemaybelesserwithdietaryinclusionofcurcumin,butrequiresmoreevidence ColorectalCancerRisk Minor VeryHigh See2studies Appearstobeassociatedwithareducedriskforcoloncancer DNADamage Minor - Seestudy AdecreaseinDNAdamagehasbeennotedtobesecondarytoreducingarsenictoxicity Edema Minor - Seestudy Adecreaseinedemahasbeennotedwithcurcuminsupplementation Fatigue Minor - Seestudy Adecreaseinpostoperativefatiguehasbeennotedwithcurcuminsupplementation Insulin Minor - Seeall13studies Mayincreasepostprandialinsulinconcentrations,andadecrease,whentakenchronically,ispossiblebutunreliablefromstudies. InsulinSecretion Minor VeryHigh Seeall3studies Curcuminhasbeenfoundtoincreaseinsulinsecretionininsulinresistantpersons,suggestingbenefitstopancreatictissue. InsulinSensitivity Minor - Seestudy Ininsulinresistantpersons,curcumincanincreaseinsulinsensitivity. Interleukin1-beta Minor VeryHigh Seeall3studies AreductioninIL-1bhasbeennotedinosteoarthriticpatients,whichisthoughttounderliethebenefitstojointhealthseenwithcurcumin. Interleukin6 Minor VeryHigh Seeall5studies AslightdecreaseinIL-6concentrationshasbeennoted,practicalrelevanceunknown. IntestinalMotility Minor - Seestudy Mayincreaseintestinalmotility KidneyFunction Minor VeryHigh See2studies Appearstopromotekidneyfunctionininstanceswherefunctionisnormallyhindered Mucositis Minor - Seestudy Symptomsofmucositishavebeennotedtobedecreasedwithcurcuminsupplementation Myeloperoxidase Minor - Seestudy AslightincreaseinMPOconcentrationshasbeendetected. ProstateCancerRisk Minor VeryHigh See2studies Appearstobeassociatedwithareducedriskofprostatecancerinonestudy,butanotherstudyfailedtofindclinicalimplicationsinpeoplewithprostatecancerinremission. ProstateSpecificAntigen Minor VeryHigh See2studies Hasbeennotedtodecreaseprostatespecificantigenlevelsfollowingsupplementation Proteinuria Minor - Seestudy Areductioninproteinuriahasbeennotedinpersonswithkidneyimpairmentgivencurcumin UlcerativeColitis(UC) Minor VeryHigh See2studies Symptomsofulcerativecolitisreducedwithsupplementationofcurcumin UricAcid Minor Moderate Seeall4studies Asmalldecreaseinpatientswithnon-alcoholicfattyliverdiseasehasbeennoted.Muchmoreevidenceisneeded. VascularFunction Minor - Seestudy Anincreaseinvascularfunctionhasbeennotedwithcurcuminsupplementation ArterialStiffness - Moderate Seeall5studies Noapparenteffectinonestudy. Creatinine - VeryHigh Seeall8studies Noapparenteffectinstudies. HeartRate - - Seestudy Nosignificantinfluenceonheartrateseenwithcurcuminsupplementation Hemoglobin - High Seeall4studies Inconsistentevidencefrom3studies.Muchmoreresearchisneeded. ProteinCarbonylContent - - Seestudy Nosignificantinfluenceonproteincarbonylationhasbeennotedwithcurcuminingestion SerumAlbumin - VeryHigh Seeall5studies Noapparenteffectin5studies. StomachUlcers - - Seestudy Nosignificantinfluenceonstomachulcerationdetected SymptomsofPancreatitis - - Seestudy Nosignificantinfluenceonpainassociatedwithpancreatitis Urea - VeryHigh Seeall5studies Noapparenteffectinstudies. VO₂max - - Seestudy Inpostmenopausalwomen,curcuminsupplementationdoesnotimproveVO2max. WhiteBloodCellCount - High Seeall4studies Inconsistentevidencefrom3studies.Muchmoreresearchisneeded. Homocysteine Notable - Seestudy Anotableeffectwasfoundinonestudyinobesepeoplewithahighriskofcardiovasculardisease,butmuchmoreresearchisneeded. PMS Notable - Seestudy Onestudyfoundanotablereductioninsymptomsfrom200mgofcurcumindaily,takingoneweekbeforeuntil3daysaftermenstrualbleeding.Muchmoreresearchisneededtoconfirmcurcumin'sefficacy. COVID-19Severity Minor - Seestudy Onestudyfoundthatnano-curcuminsignificantlyimprovedsomeinflammatorymarkersandclinicalsymptomsofCOVID-19. Cortisol Minor VeryHigh See2studies Areductionhasbeennotedintwostudies,butmoreresearchisneeded. Crohn’sDisease Minor - Seestudy PossiblereductionsofsymptomsassociatedwithCrohnsDisease FreeFattyAcids Minor - Seestudy Therewasamodestreductioninonestudyintype2diabetics,butmuchmoreresearchisneeded. Leptin Minor High Seeall3studies Mixedevidencesuggestingapossiblesmallreductioninpeoplewithnon-alcoholfattyliverdisease. LipoproteinLipaseActivity Minor - Seestudy Anincreasewasfoundinonestudyintype2diabetics. LiverDamage Minor Moderate See2studies Anotableeffecthasbeenfoundinpeoplewithnon-alcoholicfattyliverdiseasebutstudiesareinconsistentandlacking. LymphocyteCount Minor - Seestudy Adecreaseinpeoplewithtype2diabeteshasbeennotedinonestudy. SerumBDNF Minor - Seestudy Anincreasehasbeennotedinpatientswithmajordepression. SymptomsofDiabeticNeuropathy Minor - Seestudy Onestudynotedasmallreductioninsymptoms,Muchmoreevidenceisneeded. SymptomsofRheumatoidArthritis Minor VeryHigh See2studies Asmallimprovementinonestudyandalargeimprovementinanother.Muchmoreevidenceisneeded. TNF-Alpha Minor High Seeall3studies Asmallreductionispossible,butmuchmoreevidenceisneeded. Totalantioxidantcapacity(TAC) Minor High Seeall3studies Somestudiesnoteasmallincreaseinantioxidantcapacity,butmuchmoreresearchisneeded. ApolipoproteinA - VeryHigh See2studies Noapparenteffectinstudies. ApolipoproteinB - VeryHigh See2studies Noapparenteffectinstudies. Bilirubin - Low Seeall3studies It'sunclearifithasmuchofaneffectfromthelimitedresearch. BodyFat - High Seeall3studies Noapparenteffectin2short-termstudies. C-Peptide - Moderate See2studies Limitedandmixedevidence. CollagenDegradation - - Seestudy EndothelialFunction - - Seestudy Noapparenteffectinonestudy. Erections - - Seestudy Noapparenteffectinonestudy. Ferritin - - Seestudy Noapparenteffectinonestudy. Fructosamine - - Seestudy Noapparenteffectinonestudy. Hematocrit - - Seestudy Noapparenteffectinonestudy. Interleukin10 - - Seestudy Noapparenteffectinonestudy. Interleukin8 - - Seestudy Noapparenteffectinonestudy. IronAbsorption - - Seestudy Nosignificantinfluenceonironabsorptionseenwithlowlevelsofdietaryturmericintake. LiverFat - High Seeall3studies Inconsistentevidencefromnon-alcoholicfattyliverdisease. MonocyteCount - - Seestudy Adecreaseinpeoplewithtype2diabeteshasbeennoted NeutrophilCount - - Seestudy Noapparenteffectinonestudy. OxidationofLDL - Moderate See2studies Noapparenteffectinonestudyusingturmeric. QualityofLife - - Seestudy Noapparenteffectinonestudyinprostatecancerpatients. RedBloodCellCount - VeryHigh Seeall3studies Noeffectobservedinthestudiessofar. SerumPlatelets - VeryHigh See2studies Noapparenteffect. SymptomsofProstateCancer - - Seestudy Noapparenteffectinonestudy. Testosterone - - Seestudy Noapparenteffectinprostatecancerpatientswhohadtemporarilyceasedandrogendeprivationtherapy. vLDL-C - Moderate See2studies Anotablereductionwasfoundincoronaryarterydiseasepatientsinasmallpilotstudy,butnotinanotherstudyintype2diabeticsthatusedturmeric.Muchmoreresearchisneeded. Stayontopofthelatestresearch TounlockthefullarchivesofourStudyDatabaseandresearchanalyses,becomeanExamineMembertoday. Startyour14-dayfreetrial StudyDeepDives Cancurcuminreducecardiovascularriskfactors?Spicingupdepression:curcuminasanadjuncttherapyExploringcurcuminfordepressionandanxietyCurcuminforaclearnoseSpicingupyourworkoutCurry…brainfood?CurcuminreducesDOMS,withsomecaveats Showmore ClickheretobecomeanExamineMemberandstayontopofthelatestresearch. FrequentlyAskedQuestionsandArticlesonCurcumin Supplementingforbetterjointhealth Aquicklookatsupplementsproventopossiblyhelpyouwithjointpain. Readfullanswerto"Supplementingforbetterjointhealth" Curcuminupdate Theresultsofstudiesoncurcuminfordepressionandosteoarthritiscontinuetoimpress,andwhileweneedstudiesofbetterqualitytoverifytheseeffects,theresearchhasexplodedandwemaygetanswerssoonerthanlater. Readfullanswerto"Curcuminupdate" ThingstoNote IsaFormOf Cholinergic JointHealth Spice PrimaryFunction: AntioxidantandAnti-inflammatory OtherFunctions: Boneandjointhealth CognitiveFunctionandBrainHealth Cardiovascular GeneralHealth AlsoKnownAs Turmericextract,CurryExtract,Curcuma,Diferuloylmethane,JiangHuang,CurcumaLonga,1,7-bis-{3-methoxy-4-hydroxyphenyl}-1,6-heptadiene-3,5-dione DoNotConfuseWith Turmeric(Spiceitcomesfrom),Curry(mealpreparationusingTurmeric),TreeTurmeric(atermforBerberisAristata) GoesWellWith Othercurcuminoids(Curcumin,Demethoxycurcumin,Bimethoxycurcumin,Cyclocurcumin) Piperine(increasesbioavailability) Genisteinandsoyisoflavones(synergymayhelppreventprostatecancer) FishOil,particularlyDHA,forbreastcancerprevention Garcinol,fromGarciniaIndica,forcancerprevention Awidevarietyofchemotherapypharmaceuticals CautionNotice SometesttubestudiessuggestthathighconcentrationofcurcumincancauseDNAdamageaswellassuppresstheimmunesystem Curcuminisfatsoluble LimitedinvitroevidencesuggeststhatcurcuminmaycauseDNAdamageandsuppresstheimmunesystemathighconcentrations.Howthesefindingstranslatetoactualimpactonhumanhealthisunknownatthistime. Didyouknowcurcuminhasbeenresearchedinthecontextofmanyconditionsanddiseasestates?Researchsuggestscurcuminimprovesbiomarkersassociatedwithkneeosteoarthritis,ulcerativecolitis,elevatedtriglyceridelevels,type2diabetes,atherosclerosis,andnonalcoholicfattyliverdisease.Nowonderthisgold-coloredcompoundisworthitsweightin…well,gold! Stayuptodateonthisrapidly-evolvingresearchtopicwithanExamineMembership—tryfreefor14days! ResearchBreakdownonCurcumin 1.1Sources 1.2StructureandProperties 1.3FormulationsandVariants 2.1Direct 2.2Junctionpoints 2.3Indirect/Downstream 3.1Absorption 3.2Systemic 3.3Metabolism 3.4ExcretionandClearance 3.5PhaseIEnzymeInteractions 3.6KnownDrugInteractions 4.1DHAConcentration 4.2GlutaminergicNeurotransmission 4.3Cognition 4.4Stress 4.5Anxiety 4.6Depression 4.7NeuronalInjury 4.8Alzheimer'sDisease 4.9Analgesia 5.1CardiacTissue 5.2RedBloodCells 5.3Atherosclerosis 5.4Endothelium 5.5BloodFlow 5.6Triglycerides 5.7CholesterolandLipoproteins 6.1Mechanisms 6.2Bloodglucose 6.3Diabetes 7.1Mechanisms 7.2Inflammation(AdiposeTissue) 7.3Adipokines 7.4Interventions 7.5Side-effectsrelatedtoObesity 8.1AcuteProtectiveEffects 8.2Catabolism/Anabolism 8.3Glucosemetabolism 9.1DirectAntioxidativeEffects 9.2Interventions 10.1Mechanisms 10.2JointInflammationandArthritis 10.3Virology 11.1Testosterone 11.2Estrogen 12.1General(Notmechanisms) 12.2General(Mechanisms) 12.3ProstateCancer 12.4BladderCancer 13.1Autophagy 13.2Interventions 14.1Intestines 14.2Liver 14.3Kidneys 15.1Piperine 15.2Turmeric 15.3Ginger 15.4SoyIsoflavones 15.5FishOil 15.6alpha-Linolenicacid 15.7Vincristine 15.8Rolipram 15.9Iron 15.10Garcinol 16.1General 16.2Genotoxicity 16.3Teratogenicity 16.4HumanToxicity 16.5SideEffectswithSafeUsage 16.6CaseStudies Clickhere toseeall341references. Summary HowtoTake HumanEffectMatrix StudyDeepDives FAQ ThingstoNote ResearchBreakdown References Getthelatestresearch Examineisyourpartnertobetterhealth. Getaccesstothemostup-to-date,in-depthresearchreviews.Noindustryties,nosponsors,nobias. Tryfreefor14days × Thispageisregularlyupdated,toincludethemostrecentlyavailableclinicaltrialevidence. Eachmemberofourresearchteamisrequiredtohavenoconflictsofinterest,includingwithsupplementmanufacturers,foodcompanies,andindustryfunders.Theteamincludesnutritionresearchers,registereddietitians,physicians,andpharmacists.Wehaveastricteditorialprocess. Thispagefeatures341references.Allfactualclaimsare followedbyspecifically-applicablereferences. Clickhere toseethefullsetofresearchinformationandreferencesforCurcumin. 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