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Chaos Inoculation (often referred to as CI) is a keystone passive skill that grants immunity to chaos damage, but sets maximum life to 1. PathofExileWikiPleaseconsiderhelpingkeepthewikiuptodate.Checktheto-dolistofupdatesneededforversion3.14.0. Gamedataexportswillbecominglaterasthetechnicalchangesinadditiontoregularchangestakesomemoretime. READMORE PathofExileWiki Explore MainPage AllPages InteractiveMaps navigation Mainpage Communityportal Recentchanges Randompage Adminnoticeboard Knownissues FanPortal Marketplace CommunityApps CommunityWebsites PoEDiscord(#wiki) FANDOM Games Anime Movies TV Video Wikis ExploreWikis CommunityCentral StartaWiki Register Don'thaveanaccount? SignIn Advertisement in: Keystonepassiveskills ChaosInoculation Viewsource History Talk(2) KeystoneMaximumLifebecomes1,ImmunetoChaosDamage[1]Giveupeverythinginpursuitofgreatness-evenlifeitself. ChaosInoculation(oftenreferredtoasCI)isakeystonepassiveskillthatgrantsimmunitytochaosdamage,butsetsmaximumlifeto1. Althoughthecharactermustsurviveentirelyonenergyshieldinsteadoflife,immunitytochaosdamagecanbeasignificantadvantage. Contents 1Interactions 1.1Interactionwithlifereduction 1.2Bloodmagic 1.3Chaosresistancereduction/penetration 2CIbuilds 3Location 4Relateduniqueitems 5Versionhistory 6References Interactions ThechanceanddurationofbothbeingstunnedandreceivinganelementalstatusailmentsisbasedonyourbaselifebeforeCItakeseffect.MaximumLifemodifierssuchasincreasedmaximumLife,reducedmaximumLife,etc.applytothelifebeforeCIisapplied.SincethisbaselifevalueisthenoverwrittenbyCI,theonlyadvantagelifemodifiersprovidetoaCIcharacteristhereductiononstunandstatusailment. ChaosInoculationnolongergrantsimmunitydegenerationeffectofBloodRageSpell,Duration,PhysicalLevel:(1-20)Cost:(12-29)LifeCooldownTime:1.00secCanStore1Use(s)CastTime:InstantRequiresLevel16AddsabuffthatdealsPhysicalDamageovertime,whileincreasingAttackSpeedandLifeLeech.Killinganenemywhilethisbuffisactiverefreshesthebuffduration,andcangrantaFrenzyCharge.Per1%Quality:1Superior2Anomalous3Divergent0.25%increasedAttackSpeedBuffgrants0.1%chancetogainaFrenzyChargewhenyouHitaUniqueEnemyBuffgrants0.02%ofElementalAttackDamageleechedasLife(5-15)%increasedAttackSpeed1.2%ofAttackPhysicalDamageLeechedasLifeYoutake4%ofyourMaximumLifepersecondasPhysicalDamageYoutake4%ofyourMaximumEnergyShieldpersecondasPhysicalDamage25%chancetogainaFrenzyChargeonKillBasedurationis(7-10.8)secondsPlaceintoanitemsocketoftherightcolourtogainthisskill.Rightclicktoremovefromasocket.whileretainingotherbenefitsoftheskillasof2.0.0withtheBloodRagedegenerationdamagetypechangingtophysical. LowlifeconditionswillnevertriggerwhileCIisenabled.EffectssuchasPainAttunementandOnLowLifemodsongearwillnotactivate.Fortheseeffects,youmusthave50%orlessofyourcurrentmaximumlife.ChaosInoculationsetsyourmaximumlifeto1. Fulllifeconditionswillalwaystriggerbecauseyouarealwaysat100%of1life. Interactionwithlifereduction LifereductionsapplybeforeCIwhichresetslifeto1.ForexamplefromEphemeralEdgeOneHandedSwordQuality:+20%PhysicalDamage:51.3-145.8CriticalStrikeChance:5.00%AttacksperSecond:1.30WeaponRange:11RequiresLevel32,57Str,57Dex40%increasedGlobalAccuracyRating+10toIntelligence150%increasedPhysicalDamage50%increasedGlobalCriticalStrikeChance(40-50)%increasedmaximumEnergyShield10%reducedmaximumLife(0.6-1)%ofPhysicalAttackDamageLeechedasManaIntheriftbetweenfutureandpast,lifepassesquickly.. Bloodmagic WhenlinkedwithArroganceSupportAura,SupportIcon:BLevel:(1-20)Cost&ReservationMultiplier:(220-201)%CooldownTime:0.00secRequiresLevel31Supportsanyskillwithareservation.Per1%Quality:1Superior2Anomalous3DivergentSupportedSkillshave0.25%increasedAuraeffectSupportedSkillshave0.1%reducedLifeReservationSupportedSkillsdeal0.5%increasedDamageSupportedSkillshave(10-19)%increasedAuraeffectSupportedSkillsReserveLifeinsteadofManaThisisaSupportGem.Itdoesnotgrantabonustoyourcharacter,buttoskillsinsocketsconnectedtoit.PlaceintoanitemsocketconnectedtoasocketcontainingtheActiveSkillGemyouwishtoaugment.Rightclicktoremovefromasocket.,affectedskillscannotbecast,evenifitisanaurawhichwoulddrainarelativeamountofmana/health. Chaosresistancereduction/penetration SinceCIgrantsaflat-outimmunitytochaosdamage,effectsthatreduceorpenetratechaosresistance(i.e.Occultist'sVoidBeacon)havenoeffectagainstCI.[1] CIbuilds ItisgenerallybesttowaituntilyouhavehighenergyshieldbeforetakingCIbecauseit'smucheasiertosurviveonlifeatlowerlevels.Don'tbeafraidtotakelifepassiveskillsforsurvivabilitywhilelevelingup,sinceyoucanremovethemlater. CharacterswithCIareusuallymoresusceptibletostunandstatusailmentsbecauseoftheirlowbaselife.Ratherthantakingotherwiseuselesslifenodesasdescribedabove,StuncanbemitigatedbyincreasingtheStunRecoverystatwithitemsandpassivesoruniqueitemssuchasEyeofChayulaRequiresLevel20+(10-16)toallAttributes20%reducedmaximumLife30%increasedRarityofItemsfoundCannotbeStunnedNeverblinking,alwayswatching.ThisitemcanbetransformedwithaBlessingofChayula,SkyforthQuality:+20%EnergyShield:58RequiresLevel67,123Int+(60-120)tomaximumMana30%increasedMovementSpeed25%chancetogainaPowerChargeonCriticalStrike6%reducedManaReservedYouhavenoLifeRegenerationStunThresholdisbasedon500%ofyourManainsteadofLifeThequickdieyoung,thebrilliantgomad,andthepowerfulstandaloneinawastelandoftheirowncreation.,andValyriumRequiresLevel38+(15-25)tomaximumEnergyShield+(30-40)tomaximumEnergyShield+(30-40)%toFireResistance-40%toColdResistanceStunThresholdisbasedonEnergyShieldinsteadofLifeTheywillriseandfallinfireandblood..StatusailmentscanbereducedwithhighelementalresistancesoruniqueitemssuchasAuxiumRequiresLevel79+(60-80)tomaximumEnergyShield+(60-70)tomaximumEnergyShield+(45-55)tomaximumManaChillEffectandFreezeDurationonyouarebasedon100%ofEnergyShield(20-25)%increasedElementalDamagewithAttackSkillsperPowerCharge0.2%ofAttackDamageLeechedasManaperPowerChargeAslongasthesoulisunfettered,soisthebody.orDreamFragmentsRequiresLevel24+(20-30)%toColdResistance20%increasedmaximumMana50%increasedManaRegenerationRate+(30-40)%toColdResistanceCannotbeChilledCannotbeFrozenDoryanistumbledintoarealmofmadnessAndawokeitsMaster.. ChaosInoculationworkswellwithsomeotherkeystonepassives,suchas: GhostReaverconvertslifegainedfromlifeleechintoenergyshield.VaalPactonlydisablesanyregenerationgrantedfrompassivesthat'sconvertedbyZealot'sOathasof3.0.0 Zealot'sOathappliesliferegenerationtoenergyshield.RegeneffectsthatarebasedonmaximumlifebecomebasedonmaximumES.Notethat"regeneration"doesnotincludelifeflasks,astheyarejust"Recovery". Location ChaosInoculationislocatedonthenortheastedgeoftheskilltree. Class Distancefromstart Witch 9 Shadow 11 Scion 14 Templar 16 Ranger 19 Marauder 23 Duelist 25 Relateduniqueitems ItemBaseItemStatsMidnightBargainWandQuality:+20%PhysicalDamage:25.2-45.6CriticalStrikeChance:7.00%AttacksperSecond:1.50WeaponRange:120RequiresLevel40,131Int(22-26)%increasedSpellDamage+(10-20)toIntelligenceMinionshave(20-30)%increasedMovementSpeedMinionsdeal(50-70)%increasedDamage+1tomaximumnumberofRaisedZombies+1tomaximumnumberofSkeletons+1tomaximumnumberofSpectresReserves30%ofLifeCannotbeusedwithChaosInoculationAchillinghush,ascrapingsoundOfthingsnomoreentombedinground.AshamblinghordeisonitswayTocrushtheverylightofday.EngravedWand40(22-26)%increasedSpellDamage+(10-20)toIntelligenceMinionshave(20-30)%increasedMovementSpeedMinionsdeal(50-70)%increasedDamage+1tomaximumnumberofRaisedZombies+1tomaximumnumberofSkeletons+1tomaximumnumberofSpectresReserves30%ofLifeCannotbeusedwithChaosInoculationReplicaMidnightBargainWandQuality:+20%PhysicalDamage:25.2-45.6CriticalStrikeChance:7.00%AttacksperSecond:1.50WeaponRange:120RequiresLevel40,131Int(22-26)%increasedSpellDamage+(10-20)toIntelligenceMinionshave(40-50)%increasedMovementSpeedMinionsdeal(50-70)%increasedDamage+6tomaximumnumberofRagingSpirits+3tomaximumnumberofSummonedPhantasmsReserves30%ofLifeCannotbeusedwithChaosInoculation"Simplyincredible.Icaughtanescapingtestsubjectmyselfwithswarmsofburningskulls.Delightful!"-ResearcherOlesyaEngravedWand40(22-26)%increasedSpellDamage+(10-20)toIntelligenceMinionshave(40-50)%increasedMovementSpeedMinionsdeal(50-70)%increasedDamage+6tomaximumnumberofRagingSpirits+3tomaximumnumberofSummonedPhantasmsReserves30%ofLifeCannotbeusedwithChaosInoculation Versionhistory Version Changes 3.14.1 Thein-gameCharacterScreen(originalpatchnotewording:CharacterSheet)nowdisplays"ImmunetoChaosDamage"ifyouhavetheChaosInoculationkeystonepassiveskillallocated. 3.14.0 (Notinpatchnote)Nowdoesnotchangethedisplayedchaosresistanceto100%.[2] 3.0.0 VaalPactnowonlyappliestoleechedlife. ThepassiveskillsbehindChaosInoculationhavebeenremoved. 2.3.2 Fixedanissuewhereplayers'lifetotalscouldgetoutofsyncwhentheydiedfromdegenerationdamagewithChaosInoculationallocated. 0.10.0 ChaosInoculationnowgrantsnoadditionalenergyshieldbonus.Itscompleteimmunitytochaosdamage,synergywithBloodRageandotherskillcombosaredeemedsufficientupsidetocounteractthelifepenalty. 0.9.10e TheChaosInoculationkeystonepassiveskillnowgrants+50%EnergyShieldratherthan+80%. 0.9.7d FixedtheinteractionbetweenChaosInoculationandBloodMagicsothatthere'snocrazybuggeddeathstateanymore.Ifyoutrytoreservelifeormanawhenyouhavebothofthesekeystones,youwillnowdieproperly. 0.9.6 ChangedtheChaosInoculationkeystonesothatyour"real"lifevalueisstillusedforchecksrelatedtostunandelementalstatusailments.Thiswillmeanthatyoudon'treceivegiantstuns/chillsduetobeingreducedto1life. 0.9.5h ChaosInoculationnowgrantsamultiplicativeincreasetoEnergyShield. 0.9.5 ChaosInoculationnowgrants+80%energyshieldratherthan+20% 0.9.4 Added12KeystonePassives. ChaosInnoculation:20%increasedmaximumenergyshield.Providesimmunitytochaosdamage.Maximumlifebecomes1. References ↑Dan_GGG(February11,2016)."ChaosPenetrationvsCI?".OfficialPathofExileForums.RetrievedFebruary11,2016. ↑Mark_GGG(April17,2021)."re:CI(ChaosInoculation)notgranting100%chaosimmunityasit'ssupposedtowiththispatch".OfficialPathofExileForums.RetrievedApril20,2021. Categories: Keystonepassiveskills CommunitycontentisavailableunderCCBY-NC-SA3.0unlessotherwisenoted. Advertisement FanFeed 1 Vendorrecipesystem 2 TrialofAscendancy 3 Characterclass UniversalConquestWiki Let'sGoLuna!Wiki Club57Wiki FollowonIG TikTok JoinFanLab



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