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No safe level of caffeine consumption for pregnant women ...

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Women who are pregnant or trying for a baby should consider avoiding caffeine, researchers say Women who are pregnant or trying to conceive should be ... Nosafelevelofcaffeineconsumptionforpregnantwomenandwould-bemothers BMJ / Newsroom/Newsroom / Nosafelevelofcaffeineconsumptionforpregnantwomenandwould-bemothers Nosafelevelofcaffeineconsumptionforpregnantwomenandwould-bemothers Womenwhoarepregnantortryingforababyshouldconsideravoidingcaffeine,researcherssay Womenwhoarepregnantortryingtoconceiveshouldbeadvisedtoavoidcaffeinebecausetheevidencesuggeststhatmaternalcaffeineconsumptionisassociatedwithnegativepregnancyoutcomesandthatthereisnosafelevelofconsumption,findsananalysisofobservationalstudiespublishedinBMJEvidenceBasedMedicine. Caffeineisprobablythemostwidelyconsumedpsychoactivesubstanceinhistory,andmanypeople,includingpregnantwomenconsumeitonadailybasis. Pregnantwomenhavebeenadvisedthatconsumingasmallamountofcaffeinedailywillnotharmtheirbaby.TheUKNHS,theAmericanCollegeofObstetriciansandGynecologists,theDietaryGuidelinesforAmericansandtheEuropeanFoodSafetyAuthority(EFSA)setthislevelat200mgcaffeine,whichapproximatestoroughlytwocupsofmoderate-strengthcoffeeperday. Thisstudyundertookareviewofcurrentevidenceoncaffeine-relatedpregnancyoutcomes,todeterminewhethertherecommendedsafelevelofconsumptionforpregnantwomenissoundlybased. Throughdatabasesearches,ProfessorJackJames,ofReykjavikUniversity,Iceland,identified1,261Englishlanguagepeer-reviewedarticleslinkingcaffeineandcaffeinatedbeveragestopregnancyoutcomes. Thesewerewhittleddownto48originalobservationalstudiesandmeta-analysespublishedinthepasttwodecadesreportingresultsforoneormoreofsixmajornegativepregnancyoutcomes:miscarriage,stillbirth,lowbirthweightand/orsmallforgestationalage,pretermbirth,childhoodacuteleukaemia,andchildhoodoverweightandobesity. Atotalof42separatefindingswerereportedin37observationalstudies;ofthese32foundthatcaffeinesignificantlyincreasedriskofadversepregnancyoutcomesand10foundnoorinconclusiveassociations.Caffeine-relatedriskwasreportedwithmoderatetohighlevelsofconsistencyforallpregnancyoutcomesexceptpretermbirth. Elevenstudiesreportedonthefindingsof17meta-analyses,andin14ofthesematernalcaffeineconsumptionwasassociatedwithincreasedriskforfouradverseoutcomes:miscarriage,stillbirth,lowbirthweightand/orsmallforgestationalage,andchildhoodacuteleukaemia.Thethreeremainingmeta-analysesdidnotfindanassociationbetweenmaternalcaffeineconsumptionandpretermbirth. Nometa-analyseslookedattheassociationbetweenmaternalcaffeineconsumptionandchildhoodoverweightandobesity,butfouroffiveobservationalstudiesreportedsignificantassociations. Thisisanobservationalstudy,socan’testablishcausation,andtheauthorpointsoutthattheresultscouldbeimpactedbyotherconfoundingfactors,suchasrecallofcaffeineconsumption,maternalcigarettesmokingandmostimportantlypregnancysymptoms.Pregnancysymptomssuchasnauseaandvomitinginearlypregnancyarepredictiveofahealthypregnancyandwomenwhoexperiencethemarelikelytoreducetheircaffeineintake. Butheaddsthatthedose-responsivenatureoftheassociationsbetweencaffeineandadversepregnancyoutcomes,andthefactsomestudiesfoundnothresholdbelowwhichnegativeoutcomeswereabsent,supportslikelycausationratherthanmereassociation. ProfessorJamesconcludesthatthereis“substantialcumulativeevidence”ofanassociationbetweenmaternalcaffeineconsumptionanddiversenegativepregnancyoutcomes,specificallymiscarriage,stillbirth,lowbirthweightand/orsmallforgestationalage,childhoodacuteleukaemiaandchildhoodoverweightandobesity,butnotpretermbirth. Asaresult,headds,currenthealthrecommendationsconcerningcaffeineconsumptionduringpregnancyareinneedof“radicalrevision." "Specifically,thecumulativescientificevidencesupportspregnantwomenandwomencontemplatingpregnancybeingadvisedtoavoidcaffeine,”hesays. [Ends] 24/08/2020 Notesforeditors Research:Maternalcaffeineconsumptionandpregnancyoutcomes:anarrativereviewwithimplicationsforadvicetomothersandmothers-to-bedoi10.1136/bmjebm-2020-111432 Journal:BMJEvidenceBasedMedicine Funding:Nonedeclared LinktoAcademyofMedicalScienceslabellingsystem:https://press.psprings.co.uk/AMSlabels.pdf Peerreviewed?Yes Evidencetype:Observational;dataanalysis Subjects:Mothersandpregnantwomen BMJExpertMediaPanel Ifyouareajournalistneedingtospeaktoanexpert,pleaseclickhere. BrowseourExpertMediaPanel BMJINTHENEWS LatestcoverageofBMJinthenationalandinternationalmediaSEEBMJINTHENEWS JOINOURMEDIALIST Ifyouareajournalistwhowouldliketoreceiveourpressreleases,pleaseprovideyourdetails.GETTHELATESTPRESSRELEASES CONTACTOURMEDIARELATIONSTEAM EmailtheUKmediarelationsteamformoreinformation.CONTACTUSTODAY

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