LYCOPENE - Uses, Side Effects, and More - WebMD

Lycopene is a type of organic pigment called a carotenoid. It is related to beta-carotene and gives some vegetables and fruits (e.g., tomatoes) a red color. MENUVITAMINS&SUPPLEMENTSCENTERFindaVitaminorSupplementFindaVitaminbyConditionAssessYourVitaminNeedsDRUGSANDMEDICATIONSCENTERFindaDrugMyMedicinePillIdentifierInteractionCheckerLatestDrugNewsFindaVitaminFindaPharmacyFIRSTAIDRESOURCESFirstAidA-ZFirstAidKit&WoundCareFirstAidMobileRELATEDTOVITAMINS&SUPPLEMENTSDrugs&MedicationsPillIdentifierMyMedicineInteractionCheckerDiet&WeightManagementFood&RecipesVitamins&SupplementslycopeneLYCOPENE-Uses,SideEffects,andMoreOTHERNAME(S):All-TransLycopene,All-TransLycopène,Cis-Lycopè...ShowMoreOTHERNAME(S):All-TransLycopene,All-TransLycopène,Cis-Lycopè...ShowMoreOverviewUsesSideEffectsPrecautionsInteractionsDosingReviews(10)OverviewLycopeneisatypeoforganicpigmentcalledacarotenoid.Itisrelatedtobeta-caroteneandgivessomevegetablesandfruits(e.g.,tomatoes)aredcolor.Lycopeneisapowerfulantioxidantthatmighthelpprotectcellsfromdamage.It'sfoundintomato,watermelon,redorange,pinkgrapefruit,apricot,rosehip,andguava.Lycopeneisusedforhighbloodpressure,highcholesterol,cancer,andmanyotherconditions,butthereisnogoodscientificevidencetosupportmostoftheseuses.Uses&Effectiveness?PossiblyEffectiveforProstatecancer.Takinglycopenebymouthmightslightlyreducetheriskofdevelopingprostatecancer.Itmightalsoslightlyreducetheriskofprostatecancerreturning.PossiblyIneffectiveforBladdercancer.Peoplewhoeatmorelycopeneintheirdietdon'tseemtohavealowerriskforbladdercancer.Diabetes.Peoplewhoeatmorelycopeneintheirdietdon'tseemtohavealowerriskofdevelopingdiabetes.Thereisinterestinusinglycopeneforanumberofotherpurposes,butthereisn'tenoughreliableinformationtosaywhetheritmightbehelpful.SideEffectsWhentakenbymouth:Lycopeneiscommonlyconsumedincertainfruitsandvegetables.Whentakeninsupplements,dosesof15-45mgdailyhavebeensafelyusedforupto6months.SpecialPrecautionsandWarningsWhentakenbymouth:Lycopeneiscommonlyconsumedincertainfruitsandvegetables.Whentakeninsupplements,dosesof15-45mgdailyhavebeensafelyusedforupto6months.Pregnancyandbreast-feeding:Lycopeneislikelysafeduringpregnancyandbreast-feedingwheneatenintypicalfoodamounts.Thereisn'tenoughreliableinformationtoknowiflycopenesupplementsaresafetousewhenpregnantorbreast-feeding.Stayonthesafesideandsticktofoodamounts.Surgery:Lycopenemightslowbloodclotting.Itmightincreasetheriskofbleedingduringandaftersurgery.Stopusinglycopenesupplementsatleast2weeksbeforeascheduledsurgery.Interactions?ModerateInteractionBecautiouswiththiscombinationMedicationsthatslowbloodclotting(Anticoagulant/Antiplateletdrugs)interactswithLYCOPENELycopenemightslowbloodclotting.Takinglycopenealongwithmedicationsthatalsoslowbloodclottingmightincreasetheriskofbruisingandbleeding.DosingLycopeneiscommonlyfoundinmanyfruitsandvegetables,butparticularlyintomatoproducts,includingfreshtomatoes,tomatosauce,ketchup,andtomatojuice.A130gramservingoffreshtomatoescontains4-10mgoflycopene.Ketchupcontains3.3mgpertablespoon.Lycopenesupplementsarealsoavailable.Lycopenehasmostoftenbeenusedbyadultsindosesof15-45mgbymouthdailyforupto6months.Speakwithahealthcareprovidertofindoutwhatdosemightbebestforaspecificcondition.NextViewReferencesREFERENCES:Aebischer,C.P.,Schierle,J.,andSchuep,W.Simultaneousdeterminationofretinol,tocopherols,carotene,lycopene,andxanthophyllsinplasmabymeansofreversed-phasehigh-performanceliquidchromatography.MethodsEnzymol.1999;299:348-362.Viewabstract.Agarwal,S.andRao,A.V.Tomatolycopeneandlowdensitylipoproteinoxidation:ahumandietaryinterventionstudy.Lipids1998;33(10):981-984.Viewabstract.Agudo,A.,Esteve,M.G.,Pallares,C.,Martinez-Ballarin,I.,Fabregat,X.,Malats,N.,Machengs,I.,Badia,A.,andGonzalez,C.A.VegetableandfruitintakeandtheriskoflungcancerinwomeninBarcelona,Spain.Eur.JCancer1997;33(8):1256-1261.Viewabstract.Amir,H.,Karas,M.,Giat,J.,Danilenko,M.,Levy,R.,Yermiahu,T.,Levy,J.,andSharoni,Y.Lycopeneand1,25-dihydroxyvitaminD3cooperateintheinhibitionofcellcycleprogressionandinductionofdifferentiationinHL-60leukemiccells.NutrCancer1999;33(1):105-112.Viewabstract.Ansari,M.S.andGupta,N.P.Acomparisonoflycopeneandorchidectomyvsorchidectomyaloneinthemanagementofadvancedprostatecancer.BJU.Int2003;92(4):375-378.Viewabstract.Ansari,M.S.andGupta,N.P.Lycopene:anoveldrugtherapyinhormonerefractorymetastaticprostatecancer.Urol.Oncol.2004;22(5):415-420.Viewabstract.Aune,D.,Chan,D.S.,Vieira,A.R.,NavarroRosenblatt,D.A.,Vieira,R.,Greenwood,D.C.,andNorat,T.Dietarycomparedwithbloodconcentrationsofcarotenoidsandbreastcancerrisk:asystematicreviewandmeta-analysisofprospectivestudies.AmJClinNutr2012;96(2):356-373.Viewabstract.Azqueta,A.andCollins,A.R.CarotenoidsandDNAdamage.Mutat.Res5-1-2012;733(1-2):4-13.Viewabstract.Baghurst,P.A.,McMichael,A.J.,Slavotinek,A.H.,Baghurst,K.I.,Boyle,P.,andWalker,A.M.Acase-controlstudyofdietandcancerofthepancreas.AmJEpidemiol.7-15-1991;134(2):167-179.Viewabstract.Banerjee,S.,Jeyaseelan,S.,andGuleria,R.Trialoflycopenetopreventpre-eclampsiainhealthyprimigravidas:resultsshowsomeadverseeffects.J.Obstet.Gynaecol.Res.2009;35(3):477-482.Viewabstract.Barber,N.J.,Zhang,X.,Zhu,G.,Pramanik,R.,Barber,J.A.,Martin,F.L.,M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